变应性鼻炎儿童鼻呼出气一氧化氮浓度测定方法初探

Study on measurement of nasal nitric oxide in children with allergic rhinitis

目的探讨变应性鼻炎儿童鼻呼出气一氧化氮浓度测定的方法及临床意义。方法选择2013年9月至2014年8月无鼻部不适症状的健康儿童受试者50例(100侧鼻腔)设为对照组,将周期收治的有鼻塞、喷嚏、流涕和头痛等鼻部不适症状,经鼻腔检查及过敏原检查确诊为变应性鼻炎的58例患儿(116侧鼻腔)设为变应性鼻炎组。使用Sunvou呼出气NO测定系统,采用鼻被动呼气+静音技术检测,分别测定对照组及变应性鼻炎组儿童鼻呼出气NO含量。结果对照组儿童鼻呼出气NO浓度为(266±84)ppb,变应性鼻炎组鼻呼出气NO浓度为(426±151)ppb,两组差异有统计学意义(P<0.01)。同组不同性别儿童鼻呼出气NO浓度差异无统计学意义(P>0.05)。结论鼻呼出气NO浓度可受到受试者年龄、配合程度等多因素影响,正常值范围波动较大。但采用鼻被动呼气+静音的技术检测,操作简便、安全无创、无侵袭性,可迅速对鼻部过敏情况做出初步判断,对诊断变应性鼻炎有一定的临床意义。

Objective To investigate the measurement of nasal nitric oxide in children with allergic rhinitis. Methods A total of 50 children （100 cases of nasal cavity） without nasal symptoms were selected as the control group between September 2013 and August 2014. Another 58 children （ 116 cases of nasal cavity） with allergic rhinitis between Sep- tember 2013 and August 2014 were recruited as the allergy group. The nasal nitric oxide concentration of children flom the two groups was measured by ＇ passive nasal respiration＇ technology. Results The concentration of nasal nitric oxide in the control group was （ 266 ＋ 84 ） ppb and was （ 426 ＋ 151 ） ppb in the allergy group （ P 〈 0.01 ）. There was no significant difference in concentration of nasal nitric oxide between different genders （ P 〉 0.05 ）. Conclusion The concentration of nasal nitric oxide may be affected by age and cooperation of children. The passive nasal respiration technology is a user-friendly and noninvasive measurement for initial diagnosis of allergic rhinitis.