二妙丸对痛风症大鼠血清炎症介质的影响研究

Research on Effects of Ermiao Pill on Levels of Inflammation Mediators in Serum in Rats Gouty Model

目的:在二妙丸降低血尿酸抗痛风的作用基础上,探讨二妙丸对痛风症大鼠血清中炎症介质的影响。方法:采用乙胺丁醇和腺嘌呤造模法,开展二妙丸抗痛风的药理药效的研究。同时采用高效毛细管电泳法,对大鼠血清蛋白含量进行测定。结果:二妙丸具有降低血尿酸抗痛风的药效,并初步探究二妙丸治疗痛风的作用与血清蛋白含量有关。结论:通过研究二妙丸对痛风大鼠炎症介质的影响,为二妙丸抗痛风作用机制的研究提供科学依据。

Objective： On the basis of Ermiao Pill reducing the serum uric acid and presenting an anti-arthrolithiasis effect,to investigate the effects of Ermiao Pill on inflammation mediators in serum of rats gouty model. Methods： Establish rats model of acute gouty arthritis with ehtambutol and adenine and carry out the studies on pharmacology and efficacy of Ermiao Pill. Capillary electrolithiasis（ CE） method was used to determine the content of serum protein. Results： Ermiao Pill can reduce the serum uric acid and presents an anti-arthrolithiasis effect and the results indicate that arthrolithiasis is related to the content of serum protein. Conclusion： From the effect of Ermiao Pill on inflammation mediators in serum in rats gouty model,it can provide a scientific basis on the mechanism of Ermiao Pill anti-arthrolithasis.