天然抗脑缺血药物丁苯酞类衍生物的研究进展

Advances in Research on 3-n-Butylphthalide Derivatives as Natural Anti-ischemic Stroke Drug

丁苯酞(NBP)是我国研制的具有自主知识产权的抗脑缺血药物,具有抗血小板聚集、抗血栓、减轻脑水肿等多种生物活性。但其总体疗效不高,且极难溶于水,限制了其在临床上广泛应用,故研究人员对其进行了多方面的结构修饰与改造。综述近年来对NBP的结构改造及其衍生物的研究进展,旨在为该类药物进一步研发提供参考。

3-n-Butylphthalide （NBP） is an anti-ischemic stroke drug with independent intellectual property rights in China. NBP can inhibit platelet aggregation, reduce thrombosis-associated oxidative stress, improve microcirculation, and mitigate ischemic injury in the brain. However, its clinical application has been limited by unsatisfactory efficacy and extremely poor solubility in water. As a result, extensive structural modifications have been carried out for NBP. Recent advances in research on NBP derivatives were reviewed in this article, so as to provide references for further development of related drugs.