不同时间窗高压氧治疗对急性脑卒中患者运动功能与认知功能的影响

Influence of different time windows hyperbaric oxygen therapy on the motor function and cognitive function of acute stroke patients

目的:探讨不同时间窗高压氧治疗对急性脑卒中患者运动功能与认知功能的影响。方法:选取80例急性脑卒中患者,依据从发病到进行高压氧治疗的时间分为4组,各组20例患者,其中Ⅰ组为t≤12 h;Ⅱ组7 d≥t>12 h;Ⅲ组为t﹥7 d;Ⅳ组(对照组),该组患者未接受高压氧治疗。分别于治疗前与治疗后30 d对四组患者的运动功能(采用FMA运动功能评定法和MBI测评法)与认知功能(采用神经行为认知状态测试量表NCSE)进行评定。结果:治疗后,Ⅰ组患者运动功能各评分(上肢FMA评分、下肢FMA评分、MBI评分)与认知功能评分(NCSE评分)都明显升高,且明显高于其他各组治疗后各项评分,以上差异具有统计学意义(P<0.05)。结论:高压氧可明显改善急性脑卒中患者的运动功能和认知功能,具有较好的临床效果,且越早应用效果越好。

Objective To investigate the influence of different time windows hyperbaric oxygen therapy on motor function and cognitive function of acute stroke patients. Method 80 patients with acute stroke were selected. And based on the time from onset to hyperbaric oxygen therapy,the patients were divided into four groups,each group 20 cases. Ⅰ group,t〈 12 h; Ⅱ group,t 〉12 h,but ≤ 7 d; Ⅲ group,t 〉7 d; Ⅳ group（ control group） not received hyperbaric oxygen therapy. Before and after treatment 30 d,the motor function（ using FMA motor function assessment method and the evaluation method MBI） and cognitive function（ using Neurobehavioral cognitive Status Examination） of four groups were evaluated. Results After treatment,motor function score（ FMA score upper and lower limbs FMA score,MBI score） and cognitive function score（ NCSE score） of Ⅰ group were significantly increased,and significantly higher than other groups,these differences were statistically significant（ P〈0. 05）. Conclusion Hyperbaric oxygen can significantly improve motor function and cognitive function of patients with acute stroke,with good clinical results,and the earlier application the better the results.