56例慢性阻塞性肺疾病合并呼吸衰竭与低钠血症关系的临床分析

Clinical analysis of the relationship between 56 cases of chronic obstructive pulmonary disease with respiratory failure and hyponatremia

目的:探讨慢性阻塞性肺疾病合并呼吸衰竭的发生与低钠血症的关系。方法:选取56例患者,分为A、B、C三组,观察其血钠情况,并分析其中关系。结果:三组血钠相比,差异有显著统计学意义(P<0.01),B、C两组相比,差异有显著统计学意义(P<0.05)。慢性阻塞性肺疾病合并呼吸衰竭患者发生低血钠与下列因素有关,且Ⅱ型呼吸衰竭引起低血钠的原因较I型呼吸衰竭明显,差异有统计学意义(P<0.05)。低钠血症患者往往伴随酸碱失衡,特别是碱中毒,慢性阻塞性肺疾病合并呼吸衰竭患者呼酸并代碱及代碱发生率较高,差异有统计学意义(P<0.05)。结论:慢性阻塞性肺疾病合并呼吸衰竭与低钠血症关系密切,且其发病原因复杂,与疾病的发展程度及医源性因素有关,需要定期对其血电解质进行检测并给予及时处理,使患者的死亡率降低。

Objective To investigate the relationship between chronic obstructive pulmonary disease with respiratory failure and hyponatremia. Method 56 cases of patients were divided into A group,B group,C group,to observe the serum sodium,and analyzes the relationship between them. Results The three groups were compared,the difference was significant（ P〈0. 01）,compared to B,C two groups,there was significant difference（ P〈0. 05）. Hyponatremia was related to the following factors in patients with chronic obstructive pulmonary disease complicated with respiratory failure,and type Ⅱ respiratory failure caused by hyponatremia with type Ⅰ respiratory failure significantly,the difference was statistically significant（ P〈0. 05）. Hyponatremia often accompanied by acid- base imbalance,especially alkali poisoning,chronic obstructive pulmonary disease with respiratory failure in patients with respiratory acidosis and metabolic alkalosis and metabolic alkalosis were higher,the difference was statistically significant（ P〈0. 05）. Conclusion The combination of respiratory failure and hyponatremia in patients with chronic obstructive pulmonary disease are closely related,and its etiology is complex,related with the degree of development of the disease and iatrogenic factors,should regularly check blood electrolytes and give timely treatment,to reduce mortality.