慢性荨麻疹患者外周血中白细胞介素25、17的表达及意义

Expression of Interleukin-25 and Interleukin-17 in Peripheral Blood of Patients with Chronic Urticaria and Their Significance

目的探讨白细胞介素(IL)-25、IL-17在慢性荨麻疹患者外周血中的表达及意义。方法慢性荨麻疹患者60例,健康人对照60例,采用酶联免疫吸附试验(ELISA)检测外周血中IL-25、IL-17的水平,分析它们与病情严重程度之间的关系,以及IL-25、IL-17在慢性荨麻疹患者中表达的相关性。结果慢性荨麻疹患者外周血中IL-25、IL-17水平分别为(125.08±40.60)、(17.86±8.50)ng/L,健康对照组分别为(90.82±14.95)、(8.11±2.76)ng/L,慢性荨麻疹患者IL-25、IL-17水平较健康对照组升高,差异有统计学意义(均P<0.01),且与病情严重程度呈正相关(r分别为0.776和0.798,均P<0.01)。结论 IL-25、IL-17在慢性荨麻疹患者外周血中表达呈高水平,且与病情严重程度呈正相关。

Objective In order to detect the expression levels of interleukin （IL）-25 and IL-17 in peripheral blood of patienls with chronic urticaria （CU）. Methods Sixty patients with CU and 60 healthy people were recruited as case and control group, respectively. Enzyme-linked immunosorbent assay （ELISA） was performed to detect the serum levels of IL-25 and IL-17. Results The serum levels of IL-25 and IL-17 in the patients with CU [（125.08±40.60） ng/L, （17.86±8.50）ng/L）] were significantly higher than/hose in the healthy controls [（90.82±14.95）ng/L, （8.11 ±2.76）ng/L], （t=6.13, 8.45, respectively, P〈0.01 ）, and positively ton＇elated with the severity of CU 0=0.776, 0.798, both P〈0.01 ）. Conclusion The expressions of IL-25 and IL- 17 are elevate, d in peripheral blood of patients with CU, and positively correlated with the severity of urticaria.