复方消银膏治疗银屑病疗效及安全性研究

Efficiency and Safety of Compound Xiaoyin-ointment in Treating Psoriasis

目的观察复方消银膏治疗银屑病动物模型的疗效及其安全性。方法外用咪喹莫特刺激小鼠鼠背产生银屑病模型,外用复方消银膏A(消银膏∶丙酸氯倍他索=1∶1)、复方消银膏B(消银膏∶丙酸氯倍他索=1∶2)及对照药物治疗,8 d后观察各组疗效;对大鼠进行皮肤刺激试验、皮肤过敏试验、急性毒性试验及长期毒性试验。结果复方消银膏A、复方消银膏B均能明显改善小鼠银屑病病情,两者之间差异无统计学意义(P>0.05);对完整、破损皮肤均无刺激性、急慢性毒性,不产生致敏作用。结论复方消银膏A、复方消银膏B治疗银屑病疗效确切且相当,且安全性较高。

Objective To observe curative effect and safety of the compound Xiaoyin-ointment in tile animals model of psoriasis. Methods The mice models of psoriasis were established with topical imiquimod inunction on back skin of miee. After 8 days of treatment with topical compound Xiaoyin-ointment A（Xiaoyin-ointment：sclobetasol propionate=1：1）, B（Xiaoyinointment：clobetasol propionate=1：2） and control drug on the mice models, the curative effects of each group were observed. The skin in-itation test, skin allergic test, acute toxicitic test and chronic toxicitic test were carried out by using compound Xiaoyinointment on mice models. Results Compound A and B can improve the condition of the psoriasis mice models significantly, and there was no statistical significance （P〉0.05）. Both completed or damaged skin were non-irritating and there was no acute or chronic toxicity or anaphylactic reactions. Conclusion Compound A and B have accurate and equivalent effect, and both of them have high security.