红蓝光联合维胺脂治疗中重度痤疮115例临床应用效果及安全性探讨

Clinical applicative effect and safety of red and blue light combined with viaminate in treatment of severe acne in 115 cases

目的观察红蓝光联合维胺脂治疗中重度痤疮115例临床应用效果及安全性,探讨其临床适用性。方法选择自2013年1月-2014年6月于我院治疗的中重度痤疮患者330例,随机分为试验组和对照组各115例。观察并记录两组患者的临床疗效;对两组患者治疗前后进行GAGS评分;统计两组患者治疗前后皮疹改善情况;记录两组患者并发症发生情况。结果试验组和对照组的有效率分别为85.2%和61.7%,差异具有统计学意义（P〈0.05）;两组治疗后GAGS评分改善显著,差异有统计学意义（P〈0.05）;试验组皮疹改善情况优于对照组,差异有统计学意义（P〈0.05）;两组患者并发症发生情况比较,差异无统计学意义（P〉0.05）。结论红蓝光联合维胺脂治疗中重度痤疮临床效果显著,安全性高,适合临床长期推广应用。

Objective To observe clinical applicative effect and safety of red and blue light combined with viaminate in treatment of severe acne in 115 cases and to explore its clinical applicability. Methods 330 patients with moderate to severe acne who were treated in our hospital from January 2013 to June 2014 were selected and they were randomly divided into the experimental group and control group, with 115 in each. Clinical curative effect of patients in two groups were observed and recorded. And they were received GAGS scoring before and after treatment. In addition, improvement of rash before and after treatment and occurrence of complication of patients in two groups were recorded. Results Effective rates of the experimental group and the control group were 85.2% and 61.7% respectively, and the difference was statistically significant（P〈0.05）. GAGS scores after treatment of two groups were significantly improved and the difference was statistically significant（P〈0.05）. Improvement of rash of the experimental group was better than that of the control group and the difference was statistically significant（P〈0.05）. Occurrence of complication of patients in two groups had no significant difference and it had no statistical significance（P〉0.05）. Conclusion Red and blue light combined with viaminate in treatment of moderate to severe acne has significant clinical effect and high safety, worthy of clinical long-term promotion and application.