盐酸氨溴索与氢化可的松琥珀酸钠治疗毛细支气管炎的临床疗效对比研究

A comparative study of the clinical efficacy of ambroxol hydrochloride combined with hydrocortisone sodium succinate in the treatment of infantile bronchitis

目的探讨盐酸氨溴索与氢化可的松琥珀酸钠在治疗毛细支气管炎的临床疗效。方法选取我院2014年1月-2015年9月收治的毛细支气管炎患者共120例,按照随机数字表法分为对照组与观察组,两组患者均接受常规支气管炎治疗与护理,对照组患儿接受氢化可的松琥珀酸钠治疗,观察组患儿选择盐酸氨溴索治疗。治疗结束后比较两组患者治疗毛细支气管炎的临床效果,与毛细支气管炎相关临床症状与体征消失时间。结果观察组患儿经过雾化吸入盐酸氨溴索后毛细支气管炎的临床治疗显效率为75%,明显高于对照组毛细支气管炎治疗显效率40%,差异有统计学意义（P〈0.05）。观察组患儿毛细支气管炎相关临床症状或体征如气促、憋喘、湿啰音、咳嗽消失时间均明显短于对照组,差异有统计学意义（P〈0.05）。结论雾化吸入盐酸氨溴索治疗毛细支气管炎有较好的临床疗效,能有效缩短毛细支气管炎相关症状与体征,安全有效,值得临床推广运用。

Objective To investigate the ambroxol hydrochloride combined with hydrocortisone sodium succinate in treatment of children with bronchiolitis. Methods 120 children with bronchitis in our hospital from January 2014 to September 2015 were selected, divided into a control group and an observation group according to the random number table method. The two groups were treated with conventional bronchitis treatment and nursing, the control group was treated with hydrocortisone sodium succinate treatment, the observation group with ambroxol hydrochloride in the treatment of choice. After treatment, the clinical effect and the clinical symptoms and time of bronchitis symptoms disappeared between two groups were compared. Results Patients in the observation group after the atomization inhalation of ambroxol hydrochloride, the clinical effective rate was 75%, which was significantly higher than that in the control group, the bronchitis curative effect rate was 40%, the difference was statistically significant（P〈0.05）. Observation group in children with bronchiolitis related clinical symptoms or symptoms such as shortness of breath, hold wheezing, wet rales, cough disappeared time were significantly shorter than that in the control group, the difference was statistically significant（P〈0.05）. Conclusion Inhalation of ambroxol hydrochloride in the treatment of infantile bronchitis has better clinical efficacy, can effectively shorten the bronchitis associated symptoms and signs, safe and effective, worthy of clinical application.