头孢曲松钠联合苄星青霉素治疗潜伏梅毒血清快速血浆反应素的转归

Study on rapid plasma reagin serum outcome of ceftriaxone sodium combined with benzathine penicillin on latent syphilis

目的探讨头孢曲松钠联合苄星青霉素治疗潜伏梅毒患者其血清快速血浆反应素(RPR)的转归变化。方法将100例潜伏梅毒患者随机分为联合组和对照组,每组各50例。联合组患者联合使用头孢曲松钠和苄星青霉素,对照组患者仅肌注苄星青霉素。观察和对比治疗后3、6、12、24个月两组患者的治愈率。结果治疗后3、6、12、24个月,联合组患者中早期潜伏期梅毒患者的治愈率均显著高于对照组早期潜伏期梅毒患者(P<0.05);联合组患者中晚期潜伏期梅毒患者的治愈率均显著高于对照组晚期潜伏期梅毒患者(P<0.05)。结论头孢曲松钠和苄星青霉素联合应用比单用苄星青霉素的疗效更显著,可有效提高潜伏梅毒的治愈率,值得推广应用。

Objective To investigate the clinical effects of ceftriaxone sodium combined with benzathine penicillin on latent syphilis patients by monitor serum rapid plasma reaction element（RPR） change. Methods 100 cases of latent syphilis patients were randomly divided into the combined group and control group, each group of 50 cases. The combined group were treated by ceftriaxone sodium and benzylpenicillin, patients in the control group were treated by benzathine penicillin only. The cure rate of two group in 2, 6, 12 and 24 months after treatment were observed and compared. Results The cure rate of the combined group was significantly higher than those of the control group at 3, 6, 12 and 24 months after treatment. The cure rate of the combined group was significantly higher than that of the control group（P〈0.05）. Conclusion Ceftriaxone sodium and benzathine penicillin combined has a better clinical efficacy than benzathine penicillin treated only, which can effectively improve the cure rate of latent syphilis, is worth for popularization and application.