Wnt/β-catenin信号通路参与脑缺血后神经血管单元调控及相关药物的研究进展

Advances in studies on regulating effects of Wnt/β-catenin signaling pathway on neurovascular unit after cerebral Ischemia and related medicine

Wnt信号通路广泛存在于各种生物中,参与调控细胞增殖、分化、凋亡等多种生理病理过程。近年来的研究发现,Wnt/β-catenin信号通路在缺血性脑中风神经血管单元保护中可能发挥重要调控作用。舒林酸、雌二醇等化药,红景天等含苷类成分的中药,姜黄等含挥发油的中药以及丹龙醒脑方等复方可通过调控该通路发挥神经血管保护作用。该文拟对近年来Wnt/β-catenin信号通路在缺血性脑中风后神经血管单元保护中的调节作用等相关研究进展以及目前通过调控该信号通路发挥神经血管保护作用的化学药及中药予以综述,以期为缺血性脑中风的药物改善机制提供方法学基础,同时为研究降低中风后遗症致残率新药提供思路。

Wnt signals widely exist in live creatures,involved in many physical or pathological processes,including the cell proliferation,differentiation and apoptosis.Recent studies show that Wnt/β-catenin signaling pathway may play an important regulatory role in the protective effects of neurovascular unit in ischemic stroke.Some chemicals,such as sulindac and estradiol,and some compound traditional Chinese medicine which contains glycoside(e.g.rhodiola rosea),volatile oil(e.g.turmeric) and compound prescription(e.g.Dan Long Xing Nao Fang) can protect the neurovascular unit by regulating the pathway.This aims to review the research progress of the protective effects of Wnt/β-catenin signaling pathway on the neurovascular unit in ischemic stroke,with combination of chemicals and traditional Chinese medicine which can protect the neurovascular unit via Wnt /β-catenin signaling pathway.It aims to provide the methodology basis for elucidating the mechanism of drugs,and also provide a new idea for researching the new drug which can reduce the disability rate caused by sequela of stroke.