雷公藤甲素对足细胞保护机制的研究进展

Research Progress on the Mechanism of Triptolide to Protect Podocyte

雷公藤甲素(Triptolide,T10),又名雷公藤内酯醇,是雷公藤多种有效提取成分中免疫抑制及抗炎作用最强的单体。近年研究发现,T10不仅能通过诱导淋巴细胞凋亡、抑制淋巴细胞增殖来减少蛋白尿、治疗肾脏疾病,还能通过多种机制对肾小球滤过屏障的重要成分足细胞起到保护作用。本文从足细胞损伤机制出发,将T10对足细胞保护机制的研究进展进行综述。

triptolide（ Triptolide,T10,Yuuna Ramasato tripterygiumwilfordii） is a variety of effective extraction of Tripterygium wilfordii monomer strongest immunosuppressive and anti-inflammatory effects of components. In recent years,T10 not only can induce lymphocyte apoptosis,inhibiting the proliferation of lymphocytes reduced proteinuria,renal disease treatment,but also to protect podocytes through a variety of mechanisms is an important component of the glomerular filtration barrier of. This paper from the perspective of the mechanism of podocyte injury,the progress in research on the protective mechanism of podocyte T10 review.