肺癌患者凝血指标水平与化疗疗效的关系

The significance of serum coagulation parameters in chemotherapy effect and disease assessment in lung cancer patients

目的:探讨肺癌患者血浆中凝血指标水平的变化,并分析其与化疗疗效的关系。方法:收集2010年1月-2013年1月我院初治肺癌患者165例,依照化疗疗效分为有效组(58例)和无效组(107例),另收集50例体检健康者为对照组。观察肺癌患者及正常对照组血浆的APTT、FIB、TT、D-D、FDP、AT、PT、INR、PLT、PDW水平;对肺癌患者有效组与无效组化疗前后上述凝血指标进行分析比较。结果:肺癌组化疗前PLT、FIB、D-D、FDP水平明显高于对照组(P<0.05);化疗后有效组FIB、D-D、FDP、PLT及APTT水平较化疗前明显降低,差异有统计学意义(P<0.05);化疗后无效组FIB、D-D、FDP水平明显高于化疗前,差异有统计学意义(P<0.05)。结论:FIB、D-D、FDP、PLT的水平变化对肺癌的诊断有一定的价值,可作为化疗疗效及预后的有效判断依据之一。

Objective： To investigate the changes of coagulation parameters and analyze their functions in lung cancer. Methods： All 165 cases patients with lung cancer in our department were recruited from 2010. 1 to 2013. 1.They were divided into effective group（ 58 cases） and inactive group（ 107 cases） based on the chemotherapy outcomes. Other 50 healthy subjects were recruited as the control group. We tested the levels of APTT,FIB,TT,D- D,FDP,AT,PT,INR,PLT,PDW both in patients and healthy subjects and compared the difference between effective group and inactive group. Results： The PLT,FIB,D- D,FDP levels before chemotherapy were higher than control group（ P〈0. 05）. The TT and AT were lower than control group（ P〈0. 05）. FIB,D- D,FDP,APTT,PLT levels in effective group were lower than patients before chemotherapy（ P〈0. 05）. FIB,D- D,FDP in ineffective group were higher than patients before chemotherapy（ P〈0. 05）. Conclusion： The changes of PLT,FIB,D- D,FDP levels are helpful in the diagnosis of lung cancer and could be used to judge the chemotherapy effect and disease assessment.