转录因子Sp1和VEGF在乳腺癌中的表达和意义

Expression and clinical significance of transcription factor Sp1 and VEGF in breast cancer

目的:检测转录因子Sp1和VEGF在乳腺癌中的表达,探讨两者表达的相关性及临床意义。方法:采用免疫组织化学方法检测68例乳腺癌患者肿瘤组织及18例癌旁组织中Sp1和VEGF的表达。结果:Sp1和VEGF在68例乳腺癌中表达的阳性率分别为72.05%(49/68)和64.71%(44/68),与在18例正常乳腺组织中表达阳性率(分别为33.3%和16.67%)的差异有统计学意义(P均<0.01)。Sp1的过表达与乳腺癌的TNM分期、脉管浸润及淋巴结转移相关(P<0.05),而与患者的年龄、肿瘤大小、组织学分级无明显相关性;在乳腺癌组织中Sp1和VEGF的表达之间呈明显正相关(P<0.01)。结论:Sp1和VEGF的表达与乳腺癌的生物学行为密切相关,且Sp1高表达与乳腺癌的血管生成及患者的预后相关。

Objective： To explore the relationship and clinical significance between the expressions of transcription factor Sp1 and vascular endothelial growth factor（ VEGF） in breast carcinoma. Methods： Immunohistochemical technique was used to detect the expression of Sp1 and VEGF in 68 specimens of breast cancer tissue and 18 specimens of adjacent normal breast tissue. Results： There were significant differences in positive expression rates of Sp1 and VEGF between breast cancer tissues and adjacent normal breast tissues（ 72. 05% vs 33. 3%,P〈0. 01 for Sp1,and 64. 71%vs 16. 67%,P〈0. 01 for VEGF）. The expressions of Sp1 in breast cancer tissues were correlated with TNM stage,tumor invasion and lymphnode metastasis（ P〈0. 0 5）,but not correlated with age of patients,tumor size and histological grade（ P〉0. 0 5）. The Sp1 expression positively correlated with VEGF expression in breast cancer tissues（ P〈0. 01）. Conclusion： Sp1 and VEGF is closely related with the biological behavior of breast carcinoma,and overexpression of Sp1 was associated with angiogenesis and prognosis of patients in breast cancer.