超声介导二次射频消融术联合化疗治疗复发性肝转移瘤的疗效评估

Ultrasound guided by secondary radiofrequency ablation combined chemotherapy and chemotherapy for recurrent liver metastases

目的:探索对于首次行超声引导下肝转移瘤射频消融术(RFA)后复发的患者分别进行二次RFA联合化疗、单纯化疗的疗效。方法:RFA治疗肝转移瘤的患者复发后,分为A、B两个治疗组。A组进行二次RFA联合化疗治疗,B组进行单纯化疗治疗。观察两组患者治疗后的缓解率、生存质量和半年、1年、2年的生存率。结果:A组短期缓解率明显高于B组。A、B两组半年、1年、2年生活自理能力比较P<0.05,有统计学意义。A、B两组1年、2年生存率差异P<0.01,有显著统计学意义。结论:治疗RFA后复发性肝转移瘤患者,二次RFA联合化疗与单纯化疗都可以治疗单发及多发的肝内病灶,RFA组的局部疗效更让人满意,短期内缓解率高,生存期内患者生活质量高,自理能力强,能够延长生存期,优势明显。

Objective： To explore the effect for patients of recurrent liver metastases by ultrasound guided radiofrequency ablation（ RFA） patients were divided in two groups,one was treated by second RFA combined chemotherapy,the other by chemotherapy alone. Methods： Secondary RFA treatment with combination chemotherapy group A,group B with chemotherapy alone. To observe remission rate,survival quality and half year,1 year,2 years survival rate. Results： Group A short- term response rate was significantly higher than group B. In A,B groups,half year,1 year,2years life self- care ability was statistically significant（ P〈0. 05）. A,B two groups have significant difference in 1year,2 years survival rate. Conclusion： The treatment of patients with recurrent liver metastases after RFA,secondary RFA and chemotherapy to treat multiple intrahepatic lesions was satisfactory remission rate is high.