桩蛋白在胰腺癌中的表达及临床病理学意义

Expression of paxillin in human pancreatic cancer and its clinicopathological significance

目的:探讨人类胰腺癌组织中桩蛋白的表达情况及临床病理学意义。方法:应用免疫组化法分别检测47例胰腺癌组织及47例正常胰腺组织中桩蛋白的表达情况,观察其与患者临床病理参数的关系,采用χ2及Fisher's exact检验统计学方法分析实验结果。结果:免疫组化检测结果显示,胰腺癌组织中桩蛋白的表达阳性率为76.60%(36/47),明显高于正常胰腺组织29.79%(14/47),两者差异有统计学意义(P<0.05)。桩蛋白的表达与患者年龄、性别、肿瘤大小、分化程度、肿瘤位置无明显相关性(P>0.05),而与肿瘤TNM分期(P<0.05)、肿瘤浸润范围(P<0.05)、区域淋巴结转移(P<0.05)相关,差异具有统计学意义。结论:桩蛋白与胰腺癌关系密切,进一步从基因水平的研究有助于寻找胰腺癌更佳的诊断和治疗方法。

Objective： To investigate the expression of paxillin and its clinicopathological significance in pancreatic cancer patients. Methods： Forty-seven cases of pancreatic carcinoma and forty-seven cases of normal pancreatic tissue were enrolled as our subject. Immunohistochemical staining was used to detect the expression of paxillin and the relationship between paxillin and its clinicopathological parameters was analyzed. The Chi-square and Fisher＇s exact statistical methods were used to analyze the experimental results. Results： 76. 60%（ 36 /47） was showed a higher expression of paxillin in cancer site than that of normal tissue 29. 79%（ 14 /47）. The difference was statistically significant（ P〈0. 05）. The expression of paxillin had no obvious correlation with age,gender,tumor size,differentiation,and position（ P〉0. 05）. However,the expression of paxillin was positively associated with tumor TNM stage（ P〈0. 05）,infiltrating range（ P〈0. 05） and regional lymph node metastasis（ P〈0. 05）,the differences were statistically significant. Conclusion： Our data reveals that paxillin has a close relation with pancreatic cancer,further research about it from gene level might help to find a better diagnosis and treatment method.