新疆地区不同民族间结直肠癌临床病理特征及预后

Clinical and pathological characteristics and prognosis of patients with colorectal cancer in different nationalities in Xinjiang China

目的：比较新疆地区不同民族间结直肠癌患者的临床病理特征及预后。方法：收集自2008年1月至2014年6月间在新疆医科大学附属肿瘤医院接受结直肠癌手术的1824例患者的临床资料,统计分析不同民族间临床病理特征及预后情况。结果：不同民族在年龄、职业等因素构成比上有显著性差异（P=0.000）。本组病例中年龄〉60岁57.8%,在40~60岁之间33.8%,〈40岁8.4%,不同民族患者随年龄增长,结直肠癌患病比例呈升高趋势。不同民族间肿瘤部位、组织类型、大体类型、TNM分期等构成比无显著性差异（P〉0.05）。总生存时间为8~72个月,中位生存时间36个月。术后1、3和5年生存率分别是88.9%、45.8%和18.9%。其中汉族、维族、回族、哈萨克族患者术后总中位生存时间分别为35.4、36.2、38.1、34.0个月,差异无统计学意义（P〉0.05）。结论：新疆地区不同民族间结直肠癌发病率男性高于女性,老年人是结直肠癌的高发人群,但维族患者中年比例较其他民族多。不同民族间干部患者在结直肠癌患者中的比例明显高于其他职业。

Objective： To study the clinical and pathological characteristics and prognosis of patients with colorectal cancer（ CRC） in different nationalities in Xinjiang region. Methods： Clinical data of 1824 patients with CRC who underwent radical surgery in the Affiliated Tumor Hospital of Xinjiang Medical University were collected from January2008 to June 2014 and to analyze the clinical pathological features and prognosis in different nationalities. Results：Composition ratio had significant differences in age,occupation and other factors in different ethnic groups（ P =0. 000）. This group of patients aged 60 years（ 57. 8%）,ages of 40 ~ 60（ 33. 8%）,less than 40 years old（ 8. 4%）.The incidence of CRC increased with age increasing in different ethnic groups. Composition ratio had no significant difference in tumor location,histological type,general type,TNM staging in different ethnic groups（ P〈0. 05）. The total survival time was 8 ~ 72 months and the median survival time was 36 months. The survival rates of 1,3 and 5-year were 88. 9%,45. 8% and 18. 9%,respectively. The Han,Uygur,Kazak,Hui patients median overall survival time were 35. 4,36. 2,38. 1,34. 0 months,with no statistical significance（ P〉0. 05）. Conclusion： The incidence of CRC in different nationalities in Xinjiang men is higher than that of women,and the elderly is the high risk population of CRC,but the proportion of young Uighur patients is more than other ethnic groups. Cadre patients in the proportion is significantly higher than that of other occupations in different nationalities.