糖皮质激素治疗川崎病的研究进展

Research progress of corticosteroids in the treatment of Kawasaki disease

川崎病(KD)是一种好发于5岁以下婴幼儿的非特异性血管炎性疾病。临床以丙种球蛋白(IVIG)联合阿司匹林(ASP)作为其标准治疗方案取得一定的疗效,但是仍然有部分患儿表现为IVIG无反应。近年来研究表明,激素治疗KD患儿从最初的追加治疗,逐步开始成为难治性川崎病的初始治疗选择方案。文本将对近年来激素治疗川崎病的研究进展进行综述。

Kawasaki disease（KD） is a systemic vascular inflammatory disease that is often observed in infants under 5 years old. Treatment with intravenous immunoglobulin（IVIG） and aspirin（ASP） as its standard regimen has certain curative effect. Studies have shown that, treatment with corticosteroids in KD children gradually began to become the initial treatment options of refractory KD from the initial additional treatment for IVIG non-responders. This article reviewed the research progress of corticosteroids therapy for KD in recent years.