氯氮平所致体重增加的治疗进展被引量：5

Progress on treatment of clozapine-induced weight gain

导出

摘要氯氮平所致体重增加较常见,体重增加可导致患者对治疗的依从性差,影响其社会功能康复,容易并发高血压、糖尿病、高脂血症、冠心病、应力性关节炎等多种躯体疾病,而且损害患者的心理健康,及时处理氯氮平所致体重增加具有重要的意义。本文就氯氮平所致体重增加的治疗进展作一综述。 Clozapine-induced weight gain is more common, weight gain may influence treatment compliance and recovery of social function, easily accompany with a variety of physical diseases such as hypertension, diabetes, hyperlipidemia, coronary heart disease and stress arthritis, it may also influence mental health, so it is more important to timely treatment of clozapine-induced weight gain. This article made a review on progress on treatment of clozapine-induced weight gain.

作者孙振晓孙宇新于相芬

机构地区山东省临沂市精神卫生中心精神科山东大学医学院

出处《中华临床医师杂志（电子版）》 CAS 2016年第1期128-130,共3页 Chinese Journal of Clinicians(Electronic Edition)

关键词氯氮平体重增加治疗 Clozapine Weight gain Therapy

分类号 R971.4 [医药卫生—药品]

引文网络
相关文献

参考文献25

1McIlwain ME, Harrison J, Wheeler AJ, et al. Pharmacotherapy fortreatment-resistant schizophrenia[J]. Neuropsychiatr Dis Treat, 2011,7: 135-149.
2Frogley C, Taylor D, Dickens G, et al. A systematicreview of theevidence of clozapine’s anti-aggressive effects[J]. Int JNeuropsychopharmacol, 2012, 15(9): 1351-1371.
3Mamo DC. Managing suicidality in schizophrenia[J]. Can JPsychiatry, 2007, 52(6 Suppl 1): 59S-70S.
4Cohen S, Chiles J, MacNaughton A. Weight gain associated withclozapine[J]. Am J Psychiatry, 1990, 147(4): 503-504.
5Carson WH, Forbes RA. Clozapine-induced weight gain[J]. Am JPsychiatry, 1990, 147(12): 1693-1694.
6Osser DN, Najarian DM, Dufresne RL. Olanzapine increases weightand serum triglyceride levels[J]. J Clin Psychiatry, 1999, 60(11):767-770.
7Kawachi I. Psysical and psychological consequences of weightgain[J]. J Clin Psychiatry, 1999, 60(Suppl 21): 5-9.
8Greenberg I, Chan S, BlackburnG L. Nonpharmacologic andpharmacologic management of weight gain[J]. J Clin Psychiatry,1999, 60(Suppl 21): S 31-S 36.
9Green CA, Yarborough BJ, Leo MC, et al. The STRIDE weight lossand lifestyle intervention for individuals taking antipsychoticmedications: a randomized trial[J]. Am J Psychiatry, 2015, 172(1):71-81.
10喻东山,高振忠.精神科合理用药手册[M].南京:江苏科学技术出版社,2002,10:398-406.

二级参考文献25

1T Baptisata.抗精神病药物引起体重增加的机制及处理[J].精神医学论坛,2000,(3):54-60.
2American Diabetes Association,American Psychiatric Association,A2 merican Association of Clinical Endocrinologists,North American As2 sociation for the Study of Obesity.Consensus development conference on antipsychotic drugs and obesity and diabetes[J].J Clin Psychia-try,2004,65(2):267-272.
3Dixon L,Weiden P,Delahanty J,et al.Prevalence and correlates of diabetes in national schizophrenia samples[J].Schizophren Buff,2000,26(4):903-912.
4Despres JP.Health consequences of visceral obesity[J].Ann Med,2001,33(8):534.
5David JK,Elizabeth MC,Miehael S,et al.Arandomized,double-blind placebo-eontrolled trial of metformin treatment of weight gain assoeiated with initiation of atypieal antipsychotic therapy in children and adolescents[J].Am J Psychiatry,2006,2006,163(15):2072-2079.
6Alvarez-Jimenez M,Gonzalez-Blanch C,Vazquez-Barquero JL,et al.Attenuation of antipsychotic-induced weight gain with early behavioral intervention in drug-naive first-episode psychosis patients:a randomized controlled trial[J].J Clin Psychiatry,2006,67(10):1253-1260.
7Iqaki N,Tnaka M,Goto T.Markedly improved glycemic control and enhanced insulin sensitivity in a patient with type 2 diabetes complicated by a suprasellar tumor treated with pioglitatzone and metformin[J].Intein Med,2005,44(8):832-837.
8The Diabetes Prevention Program Research Group.Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in diabetes prevention program:effects of lifestyle intervention and metformin[J].Diabetes,2005,54(16):2404-2014.
9Harden KA,Cowan PA,Velasquez-Mieyer P,et al.Effects of lifestyle intervention and metformin of weight management and markers of metabolic syndrome in obese adolescents[J].J Am Acad Nurse Pract,2007,19(7):368-377.
10喻东山.抗精神病药引起体重增加及其处理[J].临床精神医学杂志,2002,12:127-127.