摘要
乙酰肝素酶是一种内切-β-葡萄糖醛酸苷酶。可以特异性的切割细胞外基质上的硫酸肝素蛋白多糖。在炎症、恶性肿瘤等病理过程中呈过度表达。在肿瘤细胞的侵袭和转移过程中发挥重要的作用。在正常生理状态下,乙酰肝素酶的基因以及蛋白的表达受到机体内多方面的调控。
Heparanase is an endo-β-glucuronidase that specifically cleaves heparan sulfate proteoglycans in the extracellular matrix.Expression of this enzyme is increased in several pathological conditions including inflammation,malignant tumor,and plays an important role in the invasion and metastasis of tumor cells.Under normal physiological conditions,the expression of heparanase is regulated by a variety of factors in the level of gene and protein.
出处
《中华临床医师杂志(电子版)》
CAS
2016年第2期270-274,共5页
Chinese Journal of Clinicians(Electronic Edition)
关键词
肿瘤浸润
肿瘤转移
基因表达调控
乙酰肝素酶
Neoplasm invasiveness
Neoplasm metastasis
Gene expression regulation Heparanase