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乙酰肝素酶在肿瘤侵袭转移中的表达及其相关调控 被引量：4

The expression of heparanase in tumor invasion and metastasis and the related regulation
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摘要 乙酰肝素酶是一种内切-β-葡萄糖醛酸苷酶。可以特异性的切割细胞外基质上的硫酸肝素蛋白多糖。在炎症、恶性肿瘤等病理过程中呈过度表达。在肿瘤细胞的侵袭和转移过程中发挥重要的作用。在正常生理状态下,乙酰肝素酶的基因以及蛋白的表达受到机体内多方面的调控。 Heparanase is an endo-β-glucuronidase that specifically cleaves heparan sulfate proteoglycans in the extracellular matrix.Expression of this enzyme is increased in several pathological conditions including inflammation,malignant tumor,and plays an important role in the invasion and metastasis of tumor cells.Under normal physiological conditions,the expression of heparanase is regulated by a variety of factors in the level of gene and protein.
作者 关瑞宇 苏继荣
机构地区 山西医科大学 山西医科大学第二医院普外科
出处 《中华临床医师杂志（电子版）》 CAS 2016年第2期270-274,共5页 Chinese Journal of Clinicians(Electronic Edition)
关键词 肿瘤浸润 肿瘤转移 基因表达调控 乙酰肝素酶 Neoplasm invasiveness Neoplasm metastasis Gene expression regulation Heparanase
分类号 R73-37 [医药卫生—肿瘤]
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参考文献38

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二级参考文献29

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中华临床医师杂志（电子版）
2016年 第2期

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