国产多西他塞不同给药方案联合小剂量卡培他滨治疗转移性乳腺癌的临床疗效观察

The clinical effect of the combination of different dosing regimens and small dose of chemotherapy for the treatment of metastatic breast cancer

目的观察国产多西多西他赛不同给药方案联合小剂量卡培他滨治疗转移性乳腺癌的疗效和不良毒副反应.方法：40例转移性乳腺癌患者均接受国产多西他赛联合小剂量卡培他滨方案治疗 ,20例多西他赛静脉每周给药剂量为 25mg/m2 ,第1、8、15天;卡培他滨 l000 mg,2次/ d,第1-21天.20例多西他赛三周给药剂量为75 mg/m2,第1天;卡培他滨 1000 mg,2次/d,第1-21天.评价两组的有效率及不良毒副反应.结果：每周组20例患者完全缓解 （CR）2例 , 部分缓解 （PR）5例,有效率（CR ＋PR）35.0% （7/20）.3周组 20 例患者完全缓解（CR）2例,部分缓解 （PR ）6例,有效率（CR＋PR ）40.0%（8/20）.3周组的 III-IV度血液学毒性、胃肠道反应及脱发乏力均较每周组高,而3周组的周围神经炎及肝功能损害较每周组低.结论：多西他赛联合卡培他滨是治疗转移性乳腺癌的有效方案之一,不同给药方案耐受性不同;周剂量多西他赛联合卡培他滨治疗转移性乳腺癌的疗效确切及毒副反应轻, 患者耐受性好,值得临床推广.

ObjeciveTo observe domestic Duoxiduo West he match different dosing regimen combined with small dose of card of capecitabine in the treatment of metastatic breast cancer efficacy and adverse events. Methods：40 cases of metastatic breast cancer were treated with docetaxel combined with small dose of capecitabine treatment, 20of them with weekly Docetaxel,about 25mg/m2,d1、8、15、20 of them with 3 weekly Docetaxel, about 75mg/m2, dl, both of them were given 1000mg Capecitabine, twice a day for 21days.Efficacy and toxicity were evaluated.Results：In weekly group 2 patient achieved CR.5 patients achieved PR.The response rate（RR ）Was 35.0%,while in 3 weekly group 2 patient achieved CR,5patients achieved PR.The response rate（RR ） Wa s 40.0%.The IV - III hematological toxicity, gastrointestinal reaction and hair loss were higher in the three week group than in the weekly group, The peripheral neuritis and liver function damage in three weeks group than a week group. Conclusion：Docetaxel combined with card capecitabine is the treatment of metastatic breast cancer one of the most effective scheme, different regimen of tolerance to different; weekly dose docetaxel combined card of capecitabine in the treatment of metastatic breast cancer curative effect and adverse reaction of light, well tolerated by patients, it is worth clinical popularization.