盐酸戊乙奎醚用于儿童支气管镜检查术前的实验分析

The experimental analysis of the use of hydrochloric acid in the children＇s bronchoscopy

目的分析盐酸戊乙奎醚在儿童支气管镜检查术前用药的有效性和安全性.方法：本实验采用随机双盲法平行对照观察.98例患儿随机分为3组,术前分别肌注阿托品、盐酸戊乙奎醚和注射用水,测定注射后15、30 min 唾液分泌量.结果：给药30 min后,阿托品组、盐酸戊乙奎醚组、注射用水组唾液分泌量分别较给药前变化（-16.86±17.71）、（-19.23±18.77）、（-2.66±16.66）mg.给药30 min后,阿托品、盐酸戊乙奎醚和注射用水组HR分别较给药前变化（82.11±19.65） 、（-5.73±9.86）和（-0.76±7.02）次/min.观察期间无严重不良反应.结论：盐酸戊乙奎醚作为儿童支气管镜术前用药,可明显减少唾液分泌,无HR增快,无明显不良反应.

ObjectiveAnalysis of the effectiveness and safety of the use of the drug in children with bronchial endoscopy in children with the use of the drug.Methods：In this experiment, a randomized double blind method was used to observe the parallel. 98 cases of children were randomly divided into 3 groups and preoperative were intramuscular injection of atropine, hydrochloric acid amyl ethyl QUIN ether and water for injection injection were determined after 15 min, 30 min saliva secretion. Using visual analogue score （VAS） method for the determination of xerostomia, adverse reactions.Results：After administration of 30 min, the amount of saliva secreted by the atropine group, the hydrochloric acid group, and the injection water group were compared with that of the （-16.86 17.71）, （-19.23 18.77）, （-2.66 16.66） mg. After administration of 30 min, the /min of the group HR were changed respectively （＋ 19.65）, （-5.73 9.86）, （82.11） and （-0.76 7.02）. No serious adverse reactions were observed during the observation period.Conclusion：The use of hydrochloric acid in the treatment of children with bronchial endoscopy can significantly reduce the secretion of saliva, no HR increased rapidly, no obvious adverse reactions.