盐酸沙格雷酯辅助支架植入术治疗下肢动脉硬化闭塞症对患者血清HCⅡ、β2-MG水平的影响分析被引量：1

下载PDF

导出

摘要目的探讨盐酸沙格雷酯联合氯吡格雷辅助支架植入术治疗下肢动脉硬化闭塞症对患者血清HCⅡ、β2-MG水平的影响.方法：选择2012年1月至2015年3月我院就诊的下肢动脉硬化闭塞症患者220例,将其随机均分为研究组和对照组,各110例,研究组采用盐酸沙格雷酯联合氯吡格雷辅助支架植入术进行治疗,对照组采用阿司匹林联合氯吡格雷辅助支架植入术进行治疗,并分别于两组患者治疗前后检测血清HCⅡ、β2-MG水平.结果：治疗后较治疗前两组血清HCⅡ水平均显著性的升高（P〈0.05）且血清β2-MG水平显著性的降低（P〈0.05）;治疗后研究组较对照组血清HCⅡ水平显著性偏高（P〈0.05）且血清β2-MG水平显著性的偏低（P〈0.05）.结论：盐酸沙格雷酯联合氯吡格雷较阿司匹林联合氯吡格雷用于下肢动脉硬化闭塞症支架置入术后能更有效的升高HCII水平和降低β2-MG水平,值得推广应用.

作者刘明阳朱红江杨志勇张春艳赵晨阳

机构地区河北省张家口市第一医院

出处《世界中医药》 CAS 2015年第A02期1501-1502,共2页 World Chinese Medicine

关键词盐酸沙格雷酯支架置入术下肢动脉硬化闭塞症血清学指标

分类号 R259 [医药卫生—中西医结合]

引文网络
相关文献

参考文献7

1Olin JW ,Sealove BA.Peripheral artery disease:current insightintothe disease and its diagnosis and treatment[J].Mayo Clinic Proc,2010,85(7):678-692.
2庄金满,李选.下肢动脉硬化闭塞症的治疗进展[J].中国微创外科杂志,2014,14(9):839-843. 被引量：24
3Charakida M , Masi S , Tousoulis D.Functional , genetic andbiochemical biomarkers of peripheral arterial disease[J].Curr Med Chem,2012,19(2):2497-2503.
4王鑫,周瑜,乔彤.下肢动脉硬化闭塞症支架置入后服用盐酸沙格雷酯的疗效观察[J].心肺血管病杂志,2013,32(2):204-206. 被引量：6
5任师颜,王非,钱松屹,樊雪强,刘鹏.盐酸沙格雷酯治疗下肢动脉硬化闭塞症的疗效观察[J].中日友好医院学报,2012,26(3):142-144. 被引量：14
6卢衡,郭平凡.血清肝素辅助因子Ⅱ活性与下肢动脉硬化闭塞症介入术后再狭窄相关[J].中南大学学报（医学版）,2015,40(2):177-181. 被引量：15
7刘海勇,赵俊卿,顾学昌.抗血小板药物对下肢动脉硬化闭塞症患者血清炎症因子影响的对比研究[J].中南药学,2013,11(12):893-896. 被引量：10

二级参考文献108

1罗小云,吴庆华,陈忠.动脉硬化性主髂动脉闭塞症血管重建的术式选择[J].中华普通外科杂志,2006,21(2):102-104. 被引量：13
2朱云峰,朱永斌,王红粉.股深动脉血流重建治疗下肢动脉硬化闭塞症[J].中华普通外科杂志,2006,21(7):488-490. 被引量：19
3Komai H,Obitsu Y,Shigematsu H.Diabetes and old age could affect long-term patency of paramalleolar distal by- pass for peripheral arterial disease in Japanese patients[J]. Circ J ,2011,75 (10) :2460-2464.
4Peacock JM,Keo HH,Duval S,et al.The incidence and health economic burden of isehemic amputation in Minneso- ta,2005-2008[J]. Prev Chronic Dis,2011,8(6):A141.
5Saxon RR,Coffman JSI,Gooding JM,et al.Long-term patency and clinical outcome of the Viabahn stent -graft for femoropopliteal artery obstructions [J].J Vasc Interv Radiol, 2007,18( 11 ) : 1341-1349.quiz 1350.
6Lauret GJ,Van Dalen HC,Hendriks HJ,et al.When is su- pervised exercise therapy considered useful in peripheral arterial occlusive disease?A nationwide survey among vascu- lar surgeons[J].Eur J Vasc Endovasc Surg,2012,43(3):308- 312.
7De Felice M,Gallo P and Masotti G.Current therapy of pe- ripheral obstructive arterial disease.The non-surgical ap- proach[J].Angiology, 1990,41 ( 1 ) : 1-11.
8Rutherford RB.Clinical staging of acute limb ischemia as the basis for choice of revascularization method:when and how to intervene[J].Semin Vasc Surg,2009,22 (1) : 5-9.
9Sultan S,Esan O and Fahy A.Nonoperative active manage- ment of critical limb ischemia:initial experience using a se- quential compression biomechanical device for limb salvage [J].Vascular, 2008,16 (3) : 130-139.
10Ruiz-Salmeron R,de la Cuesta-Diaz A,Constantino-Bermejo M,et al.Angiographic demonstration of neoangiogenesis after intra-arterial infusion of autologous bone marrow mononu- clear cells in diabetic patients with critical limb ischemia [J].Cell Transplant,2011,20(10) : 1629-1639.