中药延胡索超声体外经皮给药实验分析

目的对中药延胡索超声体外经皮给药实验进行分析.方法：选择中药延胡索乳膏0.1g作为研究对象,用药方式为超声体外经皮给药作为实验组,未采取超声体外经皮给药的作为对照组,对两组的用药情况进行分析和观察,对比两组在3分钟、5分钟及10分钟条件下的延胡索乙素累积渗透量.结果：实验组在3分钟、5分钟及10分钟条件下的延胡索乙素累积渗透量分别为（77.25±10.33）ug/mL、（97.78±10.09）ug/mL、（108.94±10.27）ug/mL;对照组在3分钟、5分钟及10分钟条件下的延胡索乙素累积渗透量分别为（15.77±5.87）ug/mL、（22.67±3.78）ug/mL、（23.69±5.69）ug/mL（P〈0.05）,差异具有统计学意义.结论：中药延胡索超声体外经皮给药的药效发挥较为显著,可推广应用于临床过程中.

Objective to Chinese medicine yanhusuo ultrasound in vitro transdermal drug delivery experimental analysis. Method to choose Chinese medicine yanhusuo cream 0.1 g as the research object,use way of ultrasonic in vitro transdermal drug delivery as the experimental group,without taking ultrasonic in vitro transdermal drug delivery as the control group,analyzes the conditions of drug utilization of the two groups and observation,compared two groups in three minutes,five minutes and 10 minutes under the condition of tetrahydropalmatine accumulating osmotic quantity. Results the experimental group in three minutes,five minutes and 10 minutes under the condition of tetrahydropalmatine accumulating osmotic quantity respectively ug/mL （77.25＋10.33）,（97.78-10.09） of ug/mL,ug/mL （108.94＋10.27）; Control group in 3 minutes,5 minutes and 10 minutes under the condition of tetrahydropalmatine accumulating osmotic quantity respectively ug/mL （15.77＋5.87）,（22.67-3.78） ug/mL,ug/mL （23.69＋5.69） （P〈0.05）,the difference is statistically significant. Conclusion Chinese medicine yanhusuo the efficacy of ultrasound in vitro percutaneous drug play a more significant,but in the process of popularization and application in clinical.