活血化痰通络法防治糖尿病周围神经病变的机制探讨

Study of mechanism on promoting blood circulation reducing phlegm removing obstruction in channels to protect and cure diabetic peripheral neuropathy

多项研究表明炎症反应、细胞凋亡、氧化应激、胰岛素抵抗、代谢紊乱等是引起糖尿病周围神经病变的重要机制。在活血化痰通络法指导下拟定的通络糖泰方具有降糖、降脂、减轻炎症反应、抑制细胞凋亡、抑制氧化应激、改善胰岛素抵抗、改善代谢紊乱等多重作用,故推断出活血化痰通络法对糖尿病周围神经病变的防治机制。

Studies have found that inflammation, cell apoptosis, oxidative stress, IR, metabolic disorders, which work together, causing diabetic peripheral neuropathy. Research finding Tongluo Tangtai prescription with promoting blood circulation reducing phlegm removing obstruction in channels has the multi-function with dropping glucose, reducing fat, lessening inflammation, inhibiting cell apoptosis, retarding oxidation, improving insulin resistance and improving metabolic disorders. It is presumed that mechanism on Tongluo Tangtai prescription postponing the progress of diabetic peripheral neuropathy.