干细胞转录因子Nanog在恶性肿瘤上皮间质转化中的作用

Role of Stem Cell Transcription Factor Nanog in Epithelial Mesenchymal Transition of Malignant Tumor Cells

近年来,在世界范围内,恶性肿瘤的发病率越来越高,严重威胁着人类的身体健康和生活质量。恶性肿瘤最主要的特征之一就是侵袭和转移,一旦进入晚期阶段或者发生转移,现阶段最常用的治疗方法如外科手术、化学治疗和放射治疗等很难对其起到理想的治疗效果。上皮间质转化是指紧密的排列规则的上皮细胞转化为疏松的排列紊乱的间充质细胞。它的主要特征是上皮标志物(如E-cadherin)的表达降低和间质标记物(如N-cadherin,vimentin)的表达升高。干细胞转录因子Nanog是维持胚胎干细胞自我更新和多潜能性的重要调控因子,它参与多种恶性肿瘤的发生与进展,如子宫内膜腺癌、胃腺癌、结直肠癌和肺腺癌等。它可以通过肿瘤干细胞样作用及上皮间质转化过程来促进肺腺癌的进展。在肝癌细胞远处转移过程中Nanog也参与了上皮间质转化过程。本研究对近年来关于转录因子Nanog在恶性肿瘤细胞上皮间质转化过程中作用的研究进行了综述和讨论。

In recent years, the increasing incidence of cancer is becoming a serious threaten to the health and quality of life all over the world. One of the most important features of malignant tumors is invasion and metastasis, once it entered the late stage or metastasis, the most commonly used treatment methods at the present stage, such as surgical, chemotherapy and radiation therapy is difficult to have an ideal therapeutic effect. Epithelial mesenchymal transition refers to the epithelial cells with tight arrangement that are transformed into loose, disordered, mesenchymal cells. Its main feature is the reduced expression of epithelial markers （such as E-ca- dherin） and the increased expression of mesenchymal markers （such as N-cadherin, vimentin）. Stem cell transcription factor Nanog is an important regulatory factor to maintain embryonic stem cell self-renewal and pluripotency. It participates in the occurrence and development of many kinds of malignant tumors, such as endometrial cancer, stomach cancer, colorectal cancer and lung adenocarcinoma. It can enhance the progression of lung adenocarcinoma by the effect of tumor stem cell-like and the process of epithelial-mesenchymal transformation. In the metastasis process of hepatocellular cells, Nanog is also involved in the epithelialmesenchymal transformation. This research reviews and discusses the studies on the role of transcription factor Nanog in the process of malignant tumor cells epithelial-mesenchymal transformation in recent years.