多烯磷脂酰胆碱联合维生素E治疗非酒精性脂肪性肝炎合并2型糖尿病患者效果研究

Research of polyene phosphatidylcholine combined with vitamin E in treatment of patients with nonalcoholic fatty liver disease and diabetes type 2

目的探讨多烯磷脂酰胆碱联合维生素E对非酒精性脂肪性肝炎合并2型糖尿病患者的治疗效果。方法将83例非酒精性脂肪性肝炎合并2型糖尿病患者随机分为两组,其中实验组给予多烯磷脂酰胆碱和维生素E治疗,对照组则给予多烯磷脂酰胆碱治疗,两组总疗程均为8 w。通过随访观察,对两种方法的治疗效果进行比较分析。采用空腹抽取静脉血测定血糖;采用上海丰汇医学科技有限公司提供的试剂盒测定血脂;采用上海科华生物工程股份有限公司提供的试剂盒检测肝功能指标;使用西门子Sequoia512超声诊断仪进行肝脏检查,用来评估脂肪肝程度。结果实验组和对照组血糖水平都有所下降,其中实验组为7.6 mmol/L,对照组为7.8 mmol/L,两组间差异没有统计学意义(P>0.05);治疗后实验组ALT和AST分别为(43.8±18.2)IU/L和(42.3±9.6)IU/L,均显著低于对照组[(59.0±10.8)IU/L和(51.5±12.2)IU/L,P<0.05];治疗后实验组甘油三脂和总胆固醇分别(1.50±0.57)mmol/L和(5.09±1.18)mmol/L,均显著低于对照组[(3.00±0.29)mmol/L和(5.78±1.23)mmol/L,P<0.05];治疗后实验组肝脏B超评分为(1.2±0.3),显著低于对照组[(1.6±0.3),P<0.05];实验组的总有效率为79.5%,显著高于对照组(54.5%,P<0.05)。结论多烯磷脂酰胆碱联合维生素E治疗非酒精性脂肪性肝炎合并2型糖尿病患者疗效优于单纯多烯磷脂酰胆碱治疗。

Objective To explore the effect of polyene phosphatidylcholine combined with vitamin E in treatment of patients with nonalcoholic fatty liver disease and diabetes type 2. Methods Eighty three patients with nonalcoholic fatty liver disease and diabetes type 2 were randomly divided into two groups. Patients in the experimental group were given polyene phosphatidylcholine and vitamin E regularly for eight weeks,and patients in the control group received polyene phosphatidylcholine alone for eitht weeks. Then,the efficacy in the two groups as respect to normalization of blood biochemistry index and serum lipids were compared. Results At the end of treatment,the blood glucose levels in experimental group and in the control group decreased,with a average of 7.6mmol/L in patients of experimental group and 7.8 mmol/L in patients of the control group;Serum ALT and AST levels in experimental group were（43.8 ±18.2） IU/L and（42.3 ±9.6） IU/L,respectively,which were significantly lower than those in the controls [（59.0±10.8） IU/L and（51.5±12.2） IU/L,P〈0.05];Blood TG and TC levels in experimental group were（1.50±0.57） mmol/L and（5.09±1.18） mmol/L,respectively,which were significantly lower than those in the controls [（3.00 ±0.29） mmol/L and（5.78 ±1.23） mmol/L,P〈0.05];The B-mode ultrasound examination index of liver in the experimental group was（1.2 ±0.3）,significantly lower than that in the controls（1.6 ±0.3）;The effective rate in the experimental group was 79.5%,significantly higher than that in the controls（54.5%,P〈0.05）. Conclusion Polyene phosphatidylcholine combined with vitamin E is more effective in the treatment of patients with nonalcoholic fatty liver disease and diabetes type 2 than polyene phosphatidylcholine alone.