缺氧对非酒精性脂肪性肝病发病的影响

Hypoxia in the pathogenesis of nonalcoholic fatty liver diseases

非酒精性脂肪性肝病(NAFLD)患者存在系统性和肝脏局部缺氧。对于呼吸睡眠暂停综合征与脂肪性肝病的研究显示机体缺氧程度与胰岛素抵抗、肝脏脂肪变、炎症和纤维化程度相关。动物实验和分子生物学研究显示缺氧及其缺氧诱导因子能促进肝细胞脂肪堆积,加速肝脏炎症、纤维化,甚至肿瘤的发生和发展。

Systematic and local hypoxia in liver is common in patients with nonalcoholic fatty liver diseases（NAFLD）.Studies on the relationship between obstructive sleep apnea and NAFLD show that the extent of hypoxia is positively correlated with insulin resistance,liver steatosis,and hepatic inflammation and fibrosis. Experiments in animals and molecular researches demonstrate that hypoxia and the hypoxia-inducible factors could promote the occurrence and progression of hepatic steatosis,inflammation,fibrosis,and even induce carcinoma in liver.