糖尿病患者唾液流率与口干相关性研究

Correlation of Salivary Flow Rate and Xerostomia in Diabetes Mellitus Patients

目的:调查糖尿病患者口干、唾液流率情况并研究其与代谢、病史的相关性。方法:入选1型、2型糖尿病患者21例和54例,同时选择年龄、性别相近的两组健康人群作为对照,在空腹状态下测定静止唾液流率,采用口干问卷(xerostomia questionnaire,XQ)评价4组人群的口干程度。结果:与对照组相比,两组糖尿病患者唾液流率均下降,但2型糖尿病下降程度较小(P>0.05);两组糖尿病患者均诉一定程度的口干,OX量表得分高于对照组(P<0.05);2型糖尿病患者唾液流率低于1型糖尿病,而OX评分高于1型糖尿病,但差异均无统计学意义(P>0.05);以HbA1C≤6%和病史≤3年(2型糖尿病患者≤5年)为依据对糖尿病患者进行亚组分析,唾液流率和口干程度组间比较差异均无统计学意义(P>0.05)。结论:糖尿病患者均有较明显的口干症状,同时唾液腺分泌均较正常人群减少,在糖尿病患者口腔保健工作中应引起重视。

Objective： To evaluate xerostomia, salivary flow rate in diabetes mellitus patients and investigate it＇s relevance to history and metabolism. Methods： Type 1 diabetes mellitus （n=21） and type 2 diabetes mellitus （n= 54） were selected, while healthy people with similar age and gender were chosen as control groups. Resting salivary flow rate was measured and xerostomia was evaluated by xerostomia questionnaire （XQ） in four groups. Results： Compared to control group, salivary flow rates of diabetes patients were decreased, but the decline degree in type 2 diabetes mellitus was small （P〉0.05）. Two diabetic mellitus groups complained xerostomia. OX scores were higher than those of control group （P〈0.05）. Salivary flow rate of type 2 diabetes mellitus Was lower than type 1 diabetes mellitus and OX score was higher than that of type 1 diabetes mellitus （P〉0.05）. Sectionalized by HbA1C ≤6M and history,3 years （type 2 diabetes mellitus≤5 years）, there was no difference in salivary flow rate and xerostomia between sectionalizations （P〉0.05）. Conclusion： Diabetes patients complain xerostomia obviously and their salivary flow rates decrease mildly compared to normal population. More attention should be paid in oral care for diabetes mellitus patients.