重组人干扰素α-2b凝胶联合阿达帕林凝胶治疗扁平疣60例的疗效观察

Effect of recombinant human interferon α-2b gel combined with Adapalene gel as a medicine in the treatment of verruca plana

目的探讨重组人干扰素α-2b凝胶和阿达帕林凝胶联合治疗扁平疣的临床疗效。方法采取重组人干扰素α-2b凝胶(观察组)或联合阿达帕林凝胶(对照组)外用治疗扁平疣患者各30例,选择健康体检者20例作为正常组,检测治疗前后扁平疣患者血清白介素-2(interleukin-2,IL-2)及干扰素-γ(interferon-γ,IFN-γ)水平变化。结果观察组有效率为96.7%,对照组有效率为73.3%,差异有统计学意义(P<0.05)。治疗前患者血清IL-2水平及IFN-γ水平均显著低于正常组(P<0.05);治疗后观察组的IL-2水平及IFN-γ水平升高(P<0.05),而对照组治疗前后IL-2、IFN-γ水平差异无显著性。结论重组人干扰素α-2b凝胶联合阿达帕林凝胶治疗扁平疣,疗效显著。

Objective To understand the effect of recombinant human interferon α-2b gel combined with Adapalene gel in the treatment of verruca plana. Method Firstly,30 patients of verruca plana were chosen as a control group of study and another 30 were chosen as an experimental group,and 20 people of sound health were chosen as a Normal group. Secondly,the control group were subject to treatment with recombinant human interferon α-2b gel while the experimental group were subject to treatment with recombinant human interferon α-2b gel combined with Adapalene gel. Next,the levels of serum interleukin-2（ IL-2） and interferon-γ（ IFN-γ） of the patients with verruca plana were detected. Findings The effectiveness rate of the experimental group was 96. 7% while that of the control group was 73. 3%（ P 〈0. 05）. The difference was statistically significant. Before being subject to treatment,the levels of serum IL-2 and interferon-γ（ IFN-γ） of the patients were significantly lower than those of the normal group（ P 〈0. 05）. After treatment,the levels of IL-2 and IFN-γ of the experimental increased significantly（ P 〈0. 05） while those of the control group before and after treatment bore no significant difference. Conclusion Recombinant human interferon α-2b gel combined with adapalene gel can serve as an effective medicine for the treatment of verruca plana.