摘要
背景：急性胃肠炎是全球第二大公共卫生问题。轮状病毒（RV）是引起成人急性胃肠炎的病原体之一,对RV感染进行积极研究可为疾病预防和控制提供依据。目的：了解上海地区成人急性胃肠炎患者中RV感染的流行病学特征。方法：采集2010年6月—2013年12月上海市长宁区定点医院成人急性胃肠炎患者的粪便标本和临床资料,采用ELISA和PCR法进行RV及其基因型检测。结果：共采集可供分析的急性胃肠炎患者粪便标本1 554份,其中男691例,女863例,平均年龄（46.19±15.59）岁。189例患者检出RV,检出率为12.2%,其中A组RV 163例（10.5%）,B/C组RV 26例（1.7%）,A组RV基因型主要为G9型（30.1%）和G1型（25.2%）。RV阳性组水样泻、呕吐症状发生率显著高于阴性组（P〈0.05）。2010、2011、2012、2013年RV检出率分别为12.2%、14.9%、6.8%和16.3%。18-39岁年龄段组RV检出率显著低于40-59岁、60-79岁、≥80岁年龄段组（8.7%对14.8%、14.2%和17.1%,P〈0.05）。RV感染流行高峰出现在每年11月至次年2月。结论：在上海地区,成人RV相关性急性胃肠炎多见于中老年人,流行高峰为冬季,A组病毒基因型以G9和G1型为主。
Background： Acute gastroenteritis is the second largest public health problem in the world. Rotavirus（ RV） is one of the pathogens of acute gastroenteritis in adults,researches focusing on RV infection may provide the basis for prevention and control of the disease. Aims： To determine the epidemiological characteristics of RV infection in adults with acute gastroenteritis in Shanghai,China. Methods： From Jun. 2010 to Dec. 2013,stool samples and clinical data in adults with acute gastroenteritis in a designated hospital in Shanghai Changning District were collected. ELISA and PCR were used to detect RV infection and its genotypes. Results： A total of 1 554 eligible stool samples from acute gastroenteritis patients were recruited,of them 691 were males and 863 were females,the mean age was（ 46. 19 ± 15. 59） years old. RV was detected in 189 patients with a detection rate of 12. 2%,163（ 10. 5%） were categorized as group A RV and 26（ 1. 7%）were group B / C RV; the most common genotypes in group A RV were G9（ 30. 1%） and G1（ 25. 2%）. Watery stool and vomiting were more prevalent in RV-positive patients than in RV-negative patients（ P 〈0. 05）. The detection rates in years2010,2011,2012 and 2013 were 12. 2%,14. 9%,6. 8% and 16. 3%,respectively. When analyzed by age group,the detection rate was significantly lower in 18-39 years group than those in 40-59,60-79,and ≥80 years groups（ 8. 7% vs.14. 8%,14. 2%,and 17. 1%,P 〈0. 05）. The peak of epidemic was from Nov. to next Feb. Conclusions： RV infectionin adults with acute gastroenteritis is more popular in middle aged and elderly people and shows a winter seasonality in Shanghai,China. The most common genotypes of group A RV are G9 and G1.
出处
《胃肠病学》
2016年第1期6-11,共6页
Chinese Journal of Gastroenterology
基金
国家卫生计生委重大传染病防治科技重大专项(2012ZX10004-211)
