格列苯脲治疗脑卒中研究进展

下载PDF

导出

摘要随着人口老龄化,脑卒中已成为全球人口死亡的第二大病因,也是患者致残的主要原因,居我国死亡病因的首位,已成为威胁人类健康和生命的疾病。脑卒中病人的预后不佳,死亡率高达60%~80%。其中颅内出血和蛛网膜下腔出血仅占脑卒中的15%,缺血性脑卒中患者成为脑卒中的＂主力军＂。

作者黄骏李小刚

机构地区四川医科大学附属第一医院神经内科

出处《泸州医学院学报》 2016年第1期88-90,共3页 Journal of Luzhou Medical College

关键词格列苯脲蛛网膜下腔出血磺脲类药物缺血性损伤细胞凋亡脑水肿胰岛素释放颅内出血动物模型血管功能紊乱

参考文献27

1Liu M. Stroke: encouragement and disappointment in clinical trials[J]. The Lancet Neurology, 2008, 7( 1 ):5-7.
2Jauss, M. Effect of daytime, weekday and year of admission on outcome in acute ischaemic stroke patients treated with thromholytictherapy. EurJ Neurol, 2010(17): 555-561.
3Marble, A. Glibenclamide, a new sulphonylurea: Whither oral hypoglycaemic agents . Drugs, 1971(1) :109-115.
4Kramer, W. The molecular interaction of sulfonylureas with [B-cell ATP-sensitive K+-channels[J]. Diabetes R.es Clin Pract, 1995(28) :$67-$80.
5Woo, S.K. The sulfonylurea receptor 1 (SUR1)-transient receptor potential melastatin 4 (Trpm4) channel[[]. J. Biol. Chem, 2013(288) :3655-3667.
6Thompson E M, Pishko G L.Inhibiti0n of SUR1 decrease the vascular permeability of cerebral metastases[J]. Neopla- sia, 2013,15(5) : 535-543.
7Tomiyama, Y. Cerebral blood flow during hemodilution and hypoxia in rats: Role of ATP-sensitive potassium channels[J]. Stroke, 1999(30) : 1942-1947.
8Ortega, F.J. Glibenclarnide enhancesneurogenesis and im-proves long-term functional recovery after transient focal cerebral ischemia]. Cereb Blood Flow Metab, 2013 (33): 356-364.
9Nedergaard, M. Dynamics of interstitial and intracellular pH in evolving brain infarct [j]. Am. J. Physiol, 1991 (260) : 581-588.
10Albert 1, Gonzale S. Ca2 release from the sarcoplasmic reticulum is required for sustained TRPM4 activity in cerebral artery smooth muscle cells[J]. Am J Physiol Cell Physiol, 2010,299(2) : 279-288.

泸州医学院学报

2016年第1期

内容加载中请稍等...