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lncRNA与miRNA相互作用对疾病的影响 被引量：27

The influence of interaction between lncRNA and miRNA on diseases
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摘要 长链非编码RNA(lncRNA)与微小RNA(miRNA)之间存在相互调控关系。lncRNA可作为一种竞争性内源性RNA(ceRNA)与miRNA相互作用,参与靶基因的表达调控,反之,miRNA可通过RNA诱导沉默复合物(RISC)调控lncRNA发挥生物学功能,两者共同参与多种疾病的发生。 There is a interaction between long con-coding RNA（ lncRNA） and microRNA（ miRNA）. lncRNA can interact with the miRNA as a competing endogenous RNA（ ceRNA） to participate in the expression regulation of target genes. Whereas miRNA can regulate lncRNA to exert biological functions by RNA-inducde silencing complex（ RISC）. The interaction between lncRNA and miRNA participates in the occurrence of various diseases together.This review summarizes the outcomes of interaction between lncRNA and miRNA on disease.
作者 易红 张政
机构地区 重庆医科大学细胞生物学及遗传学教研室
出处 《基础医学与临床》 CSCD 2016年第2期267-271,共5页 Basic and Clinical Medicine
基金 国家自然科学基金(81270912) 重庆市科委自然科学基金(CSTC2013jcyj A10044)
关键词 长链非编码RNA 微小RNA 相互作用 疾病 lncRNA miRNA interaction diseases
分类号 R346 [医药卫生—基础医学]
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参考文献25

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同被引文献198

  • 1李晓丹,王强.补肺颗粒通过调控Akt通路对慢阻肺大鼠肺组织自噬和凋亡的影响[J].武汉大学学报（医学版）,2020,41(6):904-910. 被引量：11
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基础医学与临床
2016年 第2期

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