摘要
Notch信号转导通路广泛存在于多种动物细胞中,对调节细胞的增殖、存活、分化和凋亡等过程有重要意义,其受体和配体都是跨膜蛋白,因此是介导细胞间通讯的一种重要方式。软骨的分化发育起始自间充质细胞的凝集,Notch家族在软骨形成过程中的表达呈多样性,并对软骨的发育分化呈现时间和空间的调控。在此就Notch信号转导通路的组成、分布、转导机制及其对软骨分化发育的影响进行综述。
Notch signaling widely exists in many kinds of animal cells, and it is important to regulate cell proliferation,survival, differentiation and apoptosis. As both its receptor and ligand are trans-membrane proteins, Notch signaling is significant in mediating communication between cells. The chondrogenic development and differentiation start from the agglutination of ectomesenchymal cells. Notch family expresses diversely in the formation of cartilages, regulating them depending on time and space. In this paper, the composition, distribution and transduction mechanisms of Notch signaling and its effects on chondrogenic development and differentiation were reviewed.
出处
《组织工程与重建外科杂志》
2016年第1期44-47,共4页
Journal of Tissue Engineering and Reconstructive Surgery
基金
中国医学科学院整形外科医院院所基金重大项目
关键词
NOTCH信号
软骨
发育
分化
Notch signaling
Cartilage
Development
Differentiation
