暴力犯罪嫌疑人与攻击行为精神分裂症患者血浆中5-羟色胺水平的比较

A comparative study of plasma 5-HT levels in violent criminal suspects and schizophrenia patients with aggressive behaviors

目的：研究暴力犯罪嫌疑人和有攻击行为的男性住院精神病患者血浆中5-羟色胺（5-hydroxy tryptamine,5-HT）的水平变化.方法：研究对象为男性暴力犯罪嫌疑人48例、具有攻击行为的男性住院精神分裂症患者37例、正常成年男性45例,年龄16~58岁.采用酶联免疫吸附（ELISA）试剂盒定量测定血浆中5-HT水平,统计分析各组血浆5-HT水平的差异.结果：暴力犯罪嫌疑人和有攻击行为的男性住院精神病患者血浆中5-HT水平均显著低于正常人（P〈0.01）,而暴力犯罪嫌疑人血浆5-HT水平又显著低于有攻击行为的男性住院精神病患者（P〈0.01）.结论：暴力犯罪嫌疑人和有攻击行为的男性精神病患者血浆中5-HT水平显著降低,监测有暴力倾向的罪犯和有攻击行为的精神病患者血浆5-HT水平变化,可能有助于预防和减少暴力行为的发生.

Aim：To study the change of plasma 5-hydroxy tryptamine （5-HT） level in violent criminal suspects and schizophrenia inpatients with aggressive behaviors. Methods： The subject was composed of 48 violent criminal suspects, 37 schizophrenia inpatients with aggressive behaviors and 45 healthy male a- dults, aging from 16 - 58 years. ELISA kits were used to determine the concentration of 5-HT in the plasma samples, and One-Way ANOVA test was used to study the difference of plasma 5-HT among the groups. Results： It was found that the plasma 5-HT levels of both violent criminal suspects and the schiz- ophrenia inpatients were significantly lower than that of the healthy male adults （P 〈 0. 01 ）, and that of the violent criminal suspects was even lower than that of the schizophrenia inpatients （P 〈 0. 01 ）. Conclusion：The plasma 5-HT levels of both schizophrenia inpatients with aggressive behaviors and violentcriminal suspects has significantly decreased, and violence in those people may be related to their lower plasma levels of 5-HT.