基质金属蛋白酶检测技术的研究进展

Research progress in matrix metalloproteinases detecting technology

基质金属蛋白酶是降解细胞外基质的重要酶类。在正常生理状态下,基质金属蛋白酶参与新生血管的形成及伤口的愈合;在病理状态下它参与组织重构、恶性肿瘤转移等病理进程。通过对基质金属蛋白酶检测,可以深度了解其性质及致病机理,并进一步了解病症的恶化程度,从而进行及时检测治疗。现根据基质金属蛋白酶的功能及特性,对基质金属蛋白酶活性和表达两大方面的检测技术进行了综述,为研究人员选择合适的基质金属蛋白酶检测技术提供参考。

Matrix metalloproteinases（MMPs） are important enzymes, which can degrade extracellular matrix. MMPs participate in the formation of new blood vessels and the healing of wound under the normal physiological condition, and participate in the tissue reconstruction, malignant tumor metastasis and other pathological process. Researchers can understand the nature and the pathogenic mechanism deeply by means of MMPs detection, and get further known about the deteriorated condition, so as to detect and treat diseases in time. According to the functions and features of MMPs, the detecting technology from the two aspects of the MMPs activity and expression were summarized in this article. It will provide the reference for the researchers to choose the appropriate matrix metalloproteinases detecting technology.