麝香酮含量测定分析方法的研究进展

Research Progress in Determination and Analytical Methods of Muscone

麝香是我国特有的珍贵药材和香料,具有开窍醒神、活血消肿的药理功效,应用十分广泛。麝香酮是麝香中主要的活性成分。本文综述了近几年麝香酮含量测定分析方法,即气相色谱法、气相色谱-质谱联用法、高效液相色谱法、薄层扫描法、可见分光光度法、单扫描示波极谱法和降膜结晶法等。对上述检测麝香酮含量的方法进行分析,为麝香及其药物制剂的检测和质量标准制定提供了方法和依据,也给予医学临床应用研究以指导。

Musk is a kind of precious Traditional Chinese Medicine and perfume in our country,which can induce resuscitation,activate blood and repercussive analgesic. The application of musk is very extensive. Muscone is one of the main active constituents of musk. Research progress in determination and analytical methods of muscone in recent years was thoroughly reviewed in this paper,such as gas chromatography（ GC）,Gas Chromatography- Mass Spectrometer（ GC- MS）,high performance liquid chromatography（ HPLC）,thin layer chromatography scanning method（ TLCS）,spectrophotometry,single sweep oscillopolarography and falling film crystallization,etc.Through the analysis of the above methods of detecting muscone content,this paper endeavors to provide the scientific methods and basis for the further research on quality standards for musk and pharmaceutical preparations,and guide the medical clinical application research on muscone.