抵抗素基因多态性与脑梗死的关系

Correlation between polymorphism of resistin gene and cerebral infraction

目的研究抵抗素基因-420C/G位点多态性与脑梗死之间是否存在相关性。方法采用聚合酶链反应-高温连接酶检测反应技术,对426例脑梗死患者和305例健康对照者抵抗素基因-420C/G的多态性进行分析。结果脑梗死组的总胆固醇(TC)与对照组比较,差异无统计学意义。脑梗死组的三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、血糖和血压高于对照组,而高密度脂蛋白胆固醇(HDL-C)则降低。脑梗死组患者的-420C/G基因型频率和等位基因频率与对照组比较,差异无统计学意义,两组样本都符合H-W检验。脑梗死危险因素的logistic回归分析显示,收缩压、空腹血糖、LDL-C和TG水平的差异是脑梗死的独立危险因素。结论抵抗素基因-420C/G位点多态性与脑梗死无相关性。

Objective To investigate the correlation between the polymorphism of locus-420C/G of the resistin gene and cerebral infraction.Methods The polymorphism of locus-420 C /G of the resistin gene of426 patients with cerebral infraction and 305 healthy controls was analyzed by PCR-LDR.Results The difference of TC between the cerebral infraction group and control group were not statistically significant.The TG,LDL-C,fasting blood glucose,and blood pressure of the cerebral infraction group were higher than those of the control group,while HDL-C was lower than that of the control group.The differences of genotype frequency and allele frequency of-420 C /G gene between the cerebral infraction group and control group were not statistically significant.Samples of both groups accorded with the H-W test.The logistic regression analysis showed that sytolic pressure,fasting blood glucose,LDL-C,and TG were independent risk factors of cerebral infraction.Conclusion The polymorphism of locus-420 C/G of the resistin gene does not correlate to cerebral infraction.