摘要
近30年来,白假丝酵母菌已成为导致免疫功能低下患者发病和死亡最常见的条件致病性真菌。随着临床上唑类药物的频繁使用,耐药菌株不断被检出,其耐药机制研究也备受关注。近年来,其在转录调控水平的机制研究也取得了很大进展,明确了耐药相关编码基因的顺式作用元件和反式作用因子,并部分阐述了相应的作用机制。文章就白假丝酵母菌唑类药物耐药相关的转录调控研究进展作一综述。
In recent 30 years, Candida albicans has become the most common opportunistic pathogen that causes the incidence and mortality of patients with low immunity. With the frequent use of azole antifungal drugs, azole-resistant strains are often detected. Studies on the mechanism of drug resistance have drawn more and more attention. In recent years, studies on the mechanism of transcriptional regulation have also made great progress. The cis-acting elements and trans-acting factors of the resistant-related encoding gene were identified and the acting mechanism was partially elucidated. In this paper, research advances in the transcription regulation related to azole resistance of Candida albicans are reviewed.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2016年第2期291-295,共5页
Journal of Shanghai Jiao tong University:Medical Science
基金
上海市重点专科配套课题(ZK2012A21)
上海市科委基金(15ZR1426900)
上海黄浦区卫生局基金(2012-HGG-44)
上海市黄浦区卫生系统优秀青年人才培养计划(RCPY1407)~~
关键词
白假丝酵母菌
转录调控
外排泵
靶酶
顺式作用元件
反式作用因子
Candida albicans
transcriptional regulation
efflux pump
target enzyme
cis-acting regulatory elements
trans-acting factors
