苯磺酸左旋氨氯地平联合雷米普利治疗肾性高血压患者的疗效和安全性

Efficacy and safety of levamlodipine combined with ramipril in patients with renal hypertension

目的观察苯磺酸左旋氨氯地平和雷米普利联合用药对肾性高血压患者的疗效和安全性。方法将158例肾性高血压患者随机分成A、B、C三组。A组采用苯磺酸左旋氨氯地平联合雷米普利治疗;B组单用雷米普利治疗;C组单用苯磺酸左旋氨氯地平治疗。分别记录用药前后血压、肾功能、24 h尿蛋白定量及不良反应。结果三组患者一般情况差异无统计学意义(P>0.05);用药12 W后,A组血压及24 h尿蛋白定量下降更明显,差异有统计学意义(P<0.05);A组肾功能改善更明显,但差异无统计学意义(P>0.05);不良反应发生情况的差异无统计学意义(P>0.05)。结论苯磺酸左旋氨氯地平联合雷米普利治疗肾性高血压比单用两药能更好地控制血压、降低24 h尿蛋白水平及改善肾功能,不良反应更少,疗效显著、安全,费用低,值得临床推广。

Objective We observed efficacy and safety of levamlodipine combined with ramipril in patients with renal hypertension. Methods 158 patients with renal hypertension were randomly divided into A,B and C group. The A group used levamlodipine and ramipril to treat hypertension; The B group used ramipril and the C group used levamlodipine to treat hypertension. Record blood pressure, kidney function 24 hours urine protein quantitative and adverse reactions occur before and after medication. Results Three groups of patients generally compare differences had no statistical significance（P〈0.05）;The blood pressure and 24 h urine protein quantitative of treatment group fell more obvious after treatment 12 W, and the difference was statistically significant（P〈0.05）;Renal function in the treatment group was more obvious, but the difference was not statistically significant（P〉0.05）;There was no significant difference in the incidence of adverse reactions（P〉0.05）.Conclusion Levamlodipine combined with ramipril treatment of renal hypertension than using ramipril or used levamlodipine alone can better control of blood pressure, reduce 24 hours urine protein level and improve renal function, less adverse reaction, obvious curative effect, safety, was worth of clinical promotion.