摘要
目的探讨氨基末端脑钠肽前体(NT-pro BNP)、白细胞介素-6(IL-6)及肿瘤坏死因子(TNF-α)和急性肺损伤之间的相互关系,为急性肺损伤诊断提供佐证并提示预后情况。方法随机顺序选取60例我院ICU收治的急性肺损伤患者为观察组,招募24例正常人为对照组。采用电化学发光免疫检测血浆NT-pro BNP、酶联免疫吸附试验检测IL-6及TNF-α水平变化,同时进行肺损伤评分,分析其相关性。结果 (1)急性肺损伤患者血浆NT-pro BNP、IL-6及TNF-α水平高于对照组(P<0.05);(2)血浆NT-pro BNP、IL-6及TNF-α水平与肺损伤评分呈正相关(r=0.7031;P<0.05);(3)急性肺损伤患者治疗后血浆NT-pro BNP、IL-6及TNF-α较治疗前降低(P<0.05)。结论血清NT-pro BNP、IL-6及TNF-α水平在急性肺损伤患者中上调,肺损伤评分联合血清NT-pro BNP、IL-6及TNF-α测定可作为急性肺损伤严重程度评价和预后判断的重要标志。
Objective To explore the relationship between N-terminal pro-B-type natriuretic peptide（ NT-pro BNP） and acute lung injury as well as interleukin-6（ IL-6） and tumor necrosis factor-α（ TNF-α）.Methods All 60 patients with acute lung injury were allocated to observation group and 24 normal cases were recruited to control group. The serum levels of NT-pro BNP, IL-6 and TNF-α were detected by the electrochemical luminescence immunoassay,ELISA respectively. Results（ 1） The serum NT-pro BNP,IL-6and TNF-α levels in patients with acute lung injury were higher than those in control group（ P〈0. 05）;（ 2）The serum NT-pro BNP,IL-6 and TNF-α levels were positively correlated with lung injury score（ r = 0. 7031;P〈0.05）;（ 3） After treatment,the serum NT-pro BNP,IL-6 and TNF-α levels were decreased in patients with acute lung injury（ P〈0.05）. Conclusion The serum levels of NT-pro BNP,IL-6 and TNF-α are increased in patients with acute lung injury. Lung injury score combines with serum NT-pro BNP,IL-6 and TNF-α levels are important biomarkers for acute lung injury and its prognosis.
出处
《中华肺部疾病杂志（电子版）》
CAS
2016年第1期31-35,共5页
Chinese Journal of Lung Diseases(Electronic Edition)
基金
科技厅自然科学基础研究计划(2013JC-13)
