经皮神经电刺激与穴位按压联合艾灸对减轻肺癌患者含顺铂方案化疗后胃肠道反应的对比研究

Comparison of therapeutic efficacy between transcutaneous electrical nerve stimulation and points acupressure combined with moxibustion in preventing gastrointestinal reactions caused by cisplatinbased chemotherapy of patients with lung cancer

目的探讨经皮神经电刺激(TENS)与中医穴位按压联合艾灸对减轻肺癌患者含顺铂方案化疗所致胃肠道反应的疗效。方法将100例行含顺铂方案化疗的肺癌患者随机分为TENS组和中医组,每组50例,所有患者化疗期间均给予常规抑酸、止吐治疗;在此基础上,TENS组加用TENS治疗,中医组加用穴位按压及艾灸治疗,2次/d,化疗前1 d开始,至化疗后3d结束,比较两组患者化疗第1天至第6天胃肠道反应的发生率和症状分级情况。结果 TENS组患者恶心、呕吐的发生率及症状程度与中医组无明显差异(P>0.05);TENS组患者食欲不振的发生率低于中医组,差异有统计学意义(P<0.05),同时,TENS组食欲不振的症状程度也轻于中医组,差异有统计学意义(P<0.05)。结论 TENS与中医穴位按压联合艾灸治疗均可减轻肺癌患者含顺铂方案化疗所致的胃肠道反应,在降低患者恶心、呕吐的发生率及症状程度方面两组无明显差异,但在改善食欲不振发生率和症状程度方面,TENS治疗有一定优势。

Objective To compare the therapeutic efficacy between transcutaneous electrical nerve stimulation（ TENS） and points acupressure combined with moxibustion in preventing gastrointestinal reactions caused by cisplatin-based chemotherapy of patients with lung cancer. Methods One hundred patients with lung cancer were randomly allocated to an TENS group of 50 cases and a TCM（ Traditional Chinese Medicine）group of 50 cases. During chemotherapy period,conventional anti-nausea treatments were used in both groups,and the TENS therapy were used in the TENS group while the points acupressure combined with moxibustion were used in the TCM group,twice a day,from the 1th day before chemotherapy to the 3rd day after it. Observe and compare incidences of gastrointestinal reaction and severity of symptoms in two groups from the first day to the sixth day of chemotherapy. Results The incidence and severity of nausea and vomiting have no significant difference between TENS group and TCM group（ P〉0. 05）. The incidence of anepithymia were significantly lower in TENS group than which in TCM group（ P〈0.05）; and the severity of anepithymia were significantly lighter in TENS group than which in TCM group（ P〈0.05）. Conclusions Both TENS and points acupressure combined with moxibustion are effective in preventing gastrointestinal reactions caused by cisplatin-based chemotherapy of patients with lung cancer,there is no significant difference between TENS group and TCM group in the incidence and severity of nausea and vomiting,but TENS has better effects in reducing the incidence and relieving the severity of anepithymia.