老年2型糖尿病合并冠心病患者的心率变异性研究

Heart Rate Variability in the Elderly Patients with Type 2Diabetes Combined with Coronary Heart Disease

目的:研究2型糖尿病合并冠心病老年患者的心率变异性,分析其临床意义。方法:选取42例2型糖尿病合并冠心病老年患者为观察组和30例健康老年志愿者为对照组,进行24h动态心电图检查,比较两组观察对象的心率变异性相关指标。结果:观察组患者平均心率为71.1±1.3(bpm),与对照组的71.0±1.1(bpm)无明显差异,比较差异无统计学意义(t=0.34,P>0.05)。观察组观察对象R-R间期总体标准差、平均值标准差、标准差的平均值、平方根和总R-R间期数的百分比分别为85.6±1.8(ms)、83.4±2.1(ms)、20.1±1.9(ms)、12.1±1.1(ms)和4.1±1.3(%),均低于对照组的117.1±1.2(ms)、118.1±2.7(ms)、56.7±1.6(ms)、37.2±1.5(ms)和15.2±1.2(%),比较差异有统计学意义(t=83.44、t=61.32、t=85.93、t=81.97和t=36.87,均P<0.05)。结论:心率变异性相关指标可作为2型糖尿病合并冠心病患者自主神经系统损伤评估的重要指标。

Objective： To detect the heart rate variability in the elderly patients with type 2 diabetes combined with coronary heart disease and analyze the clinical significance. Method： 42 cases of elderly patients with type 2 diabetes combined with coronary heart disease were selected as the observation group,and30 cases of elderly healthy volunteers were selected as the control group. Then the heart rate variability index of the two groups were compared. Result： The average heart rate of the observation group was 71. 1 ± 1. 3（ bpm）,compared with that of the control group 71. 0 ± 1. 1（ bpm）,there was not statistical significance（ t= 0. 34,P 0. 05）. The SDNN,SDANN,SDNNindex,RMSSD and PNN50% of the observation group were 85. 6 ± 1. 8（ ms）,83. 4 ± 2. 1（ ms）,20. 1 ± 1. 9（ ms）,12. 1 ± 1. 1（ ms） and 4. 1 ± 1. 3（ %）,which were lower than those of the control group 117. 1 ± 1. 2（ ms） 、118. 1 ± 2. 7（ ms） 、56. 7 ± 1. 6（ ms） 、37. 2 ± 1.5（ ms） and 15. 2 ± 1. 2（ %）,there were statistical significance（ t = 83. 44,t = 61. 32,t = 85. 93,t = 81. 97 and t = 36. 87,all P 0. 05）. Conclusion： The heart rate variability can be used as the important indicators of the type 2 diabetes mellitus and coronary heart disease（ CHD） patients in autonomic nervous system damage assessment.