地诺前列酮栓与缩宫素在足月胎膜早破计划分娩中的效果对比研究

Comparison of Dinoprostone Suppository and Endopituirina in the effect of Planned Delivery with Full- term Pregnancy Premature Rupture of Membranes

目的:探讨地诺前列酮栓与缩宫素在足月胎膜早破计划分娩中的有效性及安全性。方法:选取200例足月胎膜早破产妇,随机分为观察组(n=100)和对照组(n=100)。对照组给予静脉滴注缩宫素,观察组给予阴道置入地诺前列酮栓。比较两组促宫颈成熟效果、临产时间、用药至分娩时间、总产程、阴道分娩率、产后出血率及宫内感染率。结果:用药后4h,两组促宫颈成熟效果比较无统计学差异(P>0.05);用药后8h、12h及24h,观察组促宫颈成熟有效率显著高于对照组,组间比较差异具有统计学意义(P<0.05)。观察组临产时间、用药至分娩时间、总产程、阴道分娩率、产后出血率及宫内感染率分别为(22.4±4.7)h、(31.0±5.8)h、(8.4±2.9)h、79%(79/100)、2%(2/100)、0%(0/100),对照组分别为(33.5±5.1)h、(43.3±6.1)h、(10.6±3.2)h、51%(51/100)、5%(5/100)、3%(3/100)。与对照组相比较,观察组临产时间、用药至分娩时间、总产程均显著缩短,阴道分娩率显著提高,组间比较差异显著(P<0.05)。两组产后出血率及宫内感染率比较无统计学差异(P>0.05)。结论:地诺前列酮栓用于足月胎膜早破计划分娩,可有效促进宫颈成熟,缩短分娩时间,提高阴道分娩率,其效果优于缩宫素。

Objective： To evaluate the efficacy and safety of dinoprostone suppository and endopituirina on planned delivery with full- term pregnancy premature rupture of membranes. Method： 200 pregnant women with full- term pregnancy premature rupture of membranes were divided into observation group（ n =100） and control group（ n = 100）. The intravenous endopituirina was used in the control group and dinoprostone suppository by vaginal tract placement was used in the observation group. The promotion effect of cervical maturity,labor time,delivery time,total stage of labor,rate of vaginal delivery,rate of postpartum bleeding and intrauterine infection rate were compared between the two groups. Result： 4h after the treatment,the promotion effect of cervical maturity of the two groups had no statistical difference（ P〈0. 05）. 8h,12 h and 24 h after the treatment,the effect of cervical maturity of the observation group significantly higher than that of the control group,the difference showed statistical significance（ P〉0. 05）. The labor time,delivery time,total stage of labor,rate of vaginal delivery,rate of postpartum bleeding and intrauterine infection rate of the observation group respectively were（ 22. 4 ± 4. 7） h,（ 31. 0 ± 5. 8） h,（ 8. 4 ± 2. 9） h,79%（ 79 /100）,2%（ 2 /100） and 0%（ 0 /100）,those of the control group respectively were（ 33. 5 ± 5. 1） h,（ 43. 3 ± 6. 1） h,（ 10. 6 ± 3. 2） h,51%（ 51 /100）,5%（ 5 /100） and 3%（ 3 /100）. Compared with the control group,the labor time,delivery time and total stage of labor in the observation group significantly shortened,and the rate of vaginal delivery in the observation group significantly increased,the difference showed statistical significance（ P〈0. 05）. The rate of postpartum bleeding and intrauterine infection of the two groups showed no statistical difference（ P〉0. 05）. Conclusion： Dinoprostone suppository used to planned delivery with full- term pregnancy premature rupture of membranes,can effectively promote cervical mature,shorten the delivery time,improve the vaginal births,so its effect is better than that of endopituirina.