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β-细辛醚对抑郁模型大鼠海马和血清神经元特异性烯醇化酶变化的干预作用 被引量：3

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摘要 目的探讨抑郁模型大鼠海马和血清神经元特异性烯醇化酶(NSE)变化及石菖蒲有效成分β-细辛醚的干预作用。方法采用慢性轻度不可预见性应激(CUMS)结合孤笼饲养建立稳定、可行的大鼠抑郁症模型;运用旷场实验进行行为学检测;采用免疫组织化学检测对大鼠海马NSE表达量,应用ELISA方法测定血清NSE水平变化。结果与空白对照组大鼠比较,给予28 d的CUMS大鼠的自主活动得分减少,海马区神经元NSE表达量减少(P<0.05),但血清中NSE水平无显著差异;给予阳性药氟西汀(10 mg·kg^(^(-1))·d^(-1))及β-细辛醚(25 mg·kg^(-1)·d^(-1))均能显著提高CUMS大鼠的自主活动得分,海马CA3区神经元NSE表达量增多(P<0.05),但对血清中NSE水平无影响。结论β-细辛醚具有明显的抗抑郁作用,可能是通过提高神经元活性,减少神经元损伤,从而实现对CUMS大鼠神经的保护作用。
作者 刘得水 兴桂华 卢长方 高志影 张晓杰
机构地区 齐齐哈尔医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第5期1040-1041,共2页 Chinese Journal of Gerontology
基金 黑龙江省自然科学基金项目(H201354)
关键词 抑郁症 Β-细辛醚 神经元特异性烯醇化酶
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献9

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二级引证文献103

中国老年学杂志
2016年 第5期

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