广西巴马长寿人群PON1基因多态性与血脂水平的关系

Association between PON1 genes polymorphism with the serum lipid levels of Guangxi longevity population in Bama county

目的探讨广西巴马长寿人群对氧磷酶-1(PON1)基因rs662位点多态性与血脂水平的关系。方法调查巴马长寿老人151例、无长寿家族史健康成年人198例(对照1组)及南丹无长寿家族史的健康成年人176例(对照2组),分析其PON1基因频率分布特点并比较各基因型人群血脂水平。结果长寿组与对照两组的基因型和等位基因频率差异显著(P<0.05),长寿组与对照两组A等位基因频率分别为35.8%和23.0%;长寿组AG基因型的HDL水平高于GG的HDL水平,GG及G等位基因携带者的HDL水平高于对照1组,AG、GG及G等位基因携带者TG水平低于对照两组。结论长寿组与对照两组rs662位点基因型及等位基因频率分布存在差异;巴马长寿人群rs662位点多态性与血脂水平相关。

Objective To detect the association between PON1 genes polymorphism and serum lipid levels of longevity population in Bama county.Methods Genotyping of PON1 gene and serum lipid levels were performed for 151 longevous people,198 healthy controls without long life history from Bama county,176 healthy controls without long life history from Nandan.Results There was a significant difference at genotype distribution and frequencies of rs662 between longevity and control group 2.The HDL level of AG genotype was higher than GG in the longevity group.The HDL levels of GG and G allele carriers from longevity group were higher than those of contol group1; the TG levels of AG,GG and G allele carriers from longevity group lower than those of control group 2.Conclusions The alleles and genotypes distribution of rs662 exist certain differences in longevity and control group 2; rs662 loci polymorphsim has effect on TG,HDL level of longevity population.