颅颌面骨的良性纤维骨病损

Benign Fibro-Osseous Lesions of Maxillofacial Bones

颅颌面骨的良性纤维骨病损(BFOL)是在临床表现多样但具有相似的组织病理学特征的一组纤维骨性病损,在颌骨比较常见。组织病理学表现为正常的骨组织被胶原纤维和含有不同量的矿化物质的成纤维细胞所替代,矿化物可以是骨或牙骨质状外观。良性纤维骨病损包括不同性质的病变,如发育性病变,反应性或异常增生,以及肿瘤性病变。良性纤维骨病损分为三类:骨纤维异常增殖症(fibrous dysplasia,FD)、骨化纤维瘤(ossifying fibroma,OF)和骨异常增生(osseous dysplasia,OD)。本研究将从良性纤维骨病损的临床表现,组织病理学表现,影像学表现方面及现阶段的分子病理机制来对颅颌面骨的良性纤维骨病损进行复习。

The benign fibro-osseous lesions （BFOL） of the craniofacial bone are a clinically manifestations diverse group of fibro-osseous lesions with similar histologic features which is relatively common in the maxillofacial bone. Histopathology manifestations assumes that normal bone tissue is replaced by collagen fibers and fibroblasts containing different amounts of mineralized substance, which may be bony or cementum-like in appearance. BFOL includes lesions in different nature, such as developmental lesions, reactive or dysplastic processes and neoplasms. BFOL is divided into three categories： fibrous dysplasia （fibrous dysplasia, FD）, ossifying fibroma （oss- ifying fibroma, OF） and bone dysplasia （osseous dysplasia, OD）. In this research, we will review from benign fibro- osseous lesion of the clinical manifestations, histopathology manifestations, radiographicthe manifestations and the molecular pathological mechanism at the present stage of benign fibro-osseous lesions of maxillofacial bones.