骨相关细胞因子在骨生长和重塑中的作用研究进展

Progress in roles of cytokines in bone formation and remodeling

骨相关细胞因子是指在机体骨代谢过程中起重要作用的一系列细胞因子,具有调节骨生长、分化以及重塑等多种生理功能,同时也参与了骨科相关疾病的发生与治疗。缝匠肌髂骨瓣移位修复髋臼缺损治疗髋关节发育不良(DDH),临床效果良好,但是移位骨块与周围骨质的作用机制尚不明确。该文简要综述了骨形态发生蛋白(bone morphogenetic proteins,BMPs)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、转化生长因子β(transtorming grouth factor,TGF-β)、成纤维细胞生长因子(fibroblast growth factor,FGF)、胰岛素样生长因子(insulingrowth factor,IGF)在骨生成和重塑中的作用及应用,为阐明多种细胞因子在骨块修复髋臼缺损过程中的作用机制提供新的思路与方法。

Bone growth factors play an important role in the process of bone metabolism and perform a variety of physio- logical functions such as regulating bone growth, differentiation and remodeling. Meanwhile, these cytokines are associated with orthopedic disorder and therapy. The curative effect of the overturned sartorius iliac flap in repair of acetabular defect in developmental dysplasia of the hip proves to be good, but mechanism between the overturned flap and the surrounding bone tissue is unclear. This review briefly summarizes the functions and applications of severa! major cytokines in bone for- mation and remodeling, which may provide new ideas and methods for illuminating the mechanism of these cytokines during the repair of the acetabular defect.