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TWEAK及其受体在心血管疾病中的作用研究进展 被引量：7

Research progress in TWEAK and its receptor functions in cardiovascular diseases
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摘要 肿瘤坏死因子(TNF)样弱凋亡诱导因子(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)是TNF超家族的成员,与其受体成纤维细胞生长因子(FGF)诱导蛋白14(fibroblast growth factor-inducible14,Fnl4)和血浆的可溶性CD163(soluble CD163,s CD163)结合,通过相关信号通路,调节许多细胞的活性,包括增殖、迁移、凋亡、血管生成和炎症,在多种心血管疾病(如冠心病、心力衰竭、心肌病、外周血管疾病)形成和发展中起着重要的作用。该文就TWEAK及其受体在心血管疾病中的研究进展作一综述。 Tumor necrosis factor-like weak inducer of apoptosis （TWEAK） is a member of the superfamily. TWEAK binds to its receptor[ fibroblast growth factor-inducible 14 （Fnl4） and the serum level of soluble CD163 （sCD163）] and regulates many cellular activities via associated signal pathways,including proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation, which play a significant role in the formation and development of cardiovascular diseases, such as atherosclerosis, heart failure, cardiomyopathy, and peripheral vascular disease. This review summarizes functions of TWEAK and its receptor in cardiovascular diseases.
作者 洪长江 李全亮 张园
机构地区 广州军区广州总医院心内科 南方医科大学
出处 《军事医学》 CAS CSCD 北大核心 2016年第2期158-161,共4页 Military Medical Sciences
基金 国家自然科学基金资助项目(81402671)
关键词 肿瘤坏死因子样弱凋亡诱导因子 心肌梗死 心力衰竭 心肌病 动脉粥样硬化 外周血管疾病 心肌纤维化 TWEAK myocardial infarction heart failure cardiomyopathy atherosclerosis peripheral vascular disease myocardial fibrosis
分类号 R54 [医药卫生—心血管疾病]
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参考文献24

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二级参考文献41

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共引文献7

同被引文献59

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引证文献7

二级引证文献11

军事医学
2016年 第2期

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