摘要
肿瘤坏死因子(TNF)样弱凋亡诱导因子(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)是TNF超家族的成员,与其受体成纤维细胞生长因子(FGF)诱导蛋白14(fibroblast growth factor-inducible14,Fnl4)和血浆的可溶性CD163(soluble CD163,s CD163)结合,通过相关信号通路,调节许多细胞的活性,包括增殖、迁移、凋亡、血管生成和炎症,在多种心血管疾病(如冠心病、心力衰竭、心肌病、外周血管疾病)形成和发展中起着重要的作用。该文就TWEAK及其受体在心血管疾病中的研究进展作一综述。
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the superfamily. TWEAK binds to its receptor[ fibroblast growth factor-inducible 14 (Fnl4) and the serum level of soluble CD163 (sCD163)] and regulates many cellular activities via associated signal pathways,including proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation, which play a significant role in the formation and development of cardiovascular diseases, such as atherosclerosis, heart failure, cardiomyopathy, and peripheral vascular disease. This review summarizes functions of TWEAK and its receptor in cardiovascular diseases.
出处
《军事医学》
CAS
CSCD
北大核心
2016年第2期158-161,共4页
Military Medical Sciences
基金
国家自然科学基金资助项目(81402671)