康复新液联合埃索美拉唑治疗反流性食管炎临床疗效及安全性

Clinical Effects and Security of Kangfuxin Solution Combined With Esomeprazole on Reflux Esophagitis

目的观察康复新液联合埃索美拉唑治疗反流性食管炎的临床效果及安全性。方法将68例反流性食管炎患者随机分为观察组及对照组各34例,对照组给予埃索美拉唑肠溶片口服,观察组给予康复新液联合埃索美拉唑肠溶片口服,比较两组治疗8周后的临床疗效,治疗8周后内镜复查情况,以及不良反应发生情况。结果治疗8周后观察组总有效率97.1%,对照组总有效率79.4%,组间差异显著(P<0.05)。治疗8周后复查胃镜,观察组总有效率为97.1%,对照组为85.3%,组间比较差异无统计学意义(P>0.05);治疗期间两组均无明显不良反应发生。结论康复新液联合埃索美拉唑肠溶片治疗反流性食管炎可快速缓解患者临床症状,提高临床治疗效果,具有较好的安全性。

Objective To observe the clinical effects and security of kangfuxin solution combined with esomeprazole on reflux esophagitis. Methods Randomly divided the 68 patients with reflux esophagitis into observation group and control group, for each group with 34 cases. Treated the patients in control group with esomeprazole enteric-coated tablet and to the patients in observation group plus kangfuxin solution. The clinical effects of the patients in the two groups were compared 8 weeks after the treatment, the endoscope review situation and untoward effect occurrence were compared 8 weeks after the treatment. Results The total effective rate of observation group was 97.1% and that of the control group was79.4% 8 weeks after the treatment, there was a significant difference between the two groups（P〈0.05）, the total effective rate of observation group was obviously superior to that in control group 8 weeks after the treatment. Reviewed by gastroscope, the total effective rate of observation group was 97.1% and that of the control group was 85.3% 8 weeks after the treatment, there was no significant difference between the two groups（P〈0.05）, there was no obvious untoward effect occurred in the two groups during the treatment. Conclusion Kangfuxin solution combines with esomeprazole enteric-coated tablet to treat the reflux esophagitis can remit the clinical symptoms of the patients quickly, enhance the clinical therapeutic effect and with preferable security.